Selenoprotein P

An extracellular selenoprotein that contains most of the SELENIUM in PLASMA. Selenoprotein P functions as an antioxidant and appears to transport selenium from the LIVER to peripheral tissues.

Also Known As:

Networked: 220 relevant articles (7 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schomburg, Lutz: 21 articles (01/2022 - 10/2007)
2.	Takamura, Toshinari: 18 articles (08/2022 - 11/2010)
3.	Saito, Yoshiro: 17 articles (01/2022 - 11/2002)
4.	Misu, Hirofumi: 14 articles (12/2019 - 11/2010)
5.	Kaneko, Shuichi: 13 articles (08/2022 - 11/2010)
6.	Takayama, Hiroaki: 11 articles (08/2022 - 11/2010)
7.	Takeshita, Yumie: 9 articles (03/2022 - 11/2010)
8.	Köhrle, Josef: 9 articles (10/2015 - 09/2002)
9.	Takahashi, Kazuhiko: 9 articles (09/2014 - 11/2002)
10.	Burk, Raymond F: 8 articles (01/2021 - 01/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/01/2011 - "Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage." 01/01/2016 - "Higher levels of selenoprotein P were associated with a lower risk of high-grade disease (HR 0·85; 95 % CI 0·74, 0·97; P=0·01), but not with the risk of or mortality from advanced prostate cancer. " 09/01/2009 - "Because Se metabolism is controlled by selenoprotein P (SEPP), we have tested whether circulating SEPP concentrations correlate to prostate cancer stage and grade. " 09/01/2009 - "Reduced serum selenoprotein P concentrations in German prostate cancer patients." 09/15/2002 - "Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors."
2.	Neoplasms (Cancer) 10/22/2021 - "The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. " 03/01/2015 - "We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. " 01/01/2000 - "The results suggest that a low plasma selenoprotein P level is associated with higher future risk of respiratory and digestive tract cancer in middle-aged men." 01/01/2000 - "The odds ratio for overall cancer risk in the lowest quintile of selenoprotein P level compared with that in the highest was 5.2 [p (for trend) = 0.01]. " 01/01/2000 - "Selenoprotein P levels in subgroups of major cancer sites were lower in cases than in controls for the respiratory tract (1.20 and 1.30 arbitrary units, respectively; p < 0.05) cancer group. "
3.	Insulin Resistance 03/01/2022 - "Selenoprotein P (SeP, encoded by SELENOP in humans) is a hepatokine that causes insulin resistance in the liver and skeletal muscle. " 03/01/2017 - "Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. " 01/01/2017 - "These data provide a novel mechanism of action for EPA involving improvement of systemic insulin sensitivity through the regulation of selenoprotein P production independently of the AMPK pathway and suggest an additional approach to developing anti-diabetic drugs." 04/01/2016 - "Selenoprotein P levels were inversely correlated with GGT, and changes in selenoprotein P were inversely correlated with changes in homeostasis model assessment for insulin resistance (HOMA-IR). " 01/25/2014 - "Selenoprotein P (SeP) has recently been identified as a novel hepatokine that causes insulin resistance. "
4.	Colonic Neoplasms (Colon Cancer) 01/01/2004 - "Due to their antioxidative potential, the selenoproteins gastrointestinal glutathione peroxidase (GI-GPx) and selenoprotein P (SePP) are considered to provide protection against reactive oxygen species (ROS), thereby reducing DNA damage and preventing development of colon cancer. " 03/01/2002 - "The present study measured selenoprotein-P, extracellular glutathione peroxidase, and plasma selenium in patients with colon cancer and adenomatous colon polyps to determine whether patients who develop colorectal adenomas or cancer are selenium deficient. "
5.	Sepsis (Septicemia) 11/01/2022 - "Endothelial protection against ROHNS by selenoprotein-P may reduce Na2SeO3 toxicity, which is increased in sepsis. " 11/01/2022 - "Future Direction: The combination of selenoprotein-P for endothelial protection and the cytotoxic effects of Na2SeO3 against hyperactivated leukocytes may be a promising intervention for early sepsis. " 11/01/2022 - "At low concentrations, Na2SeO3 acts as a selenium donor, favoring selenoprotein-P synthesis in physiology, but probably not in the acute phase of sepsis. " 11/01/2022 - "Recent Advances: Plasma selenium (<2% of total body selenium) is mainly contained in selenoprotein-P, and concentrations decrease rapidly in the early phase of sepsis, because of increased selenoprotein-P binding and downregulation of hepatic synthesis and excretion. " 12/01/2016 - "Low serum selenium or selenoprotein P (SePP) levels have been repetitively observed in severe sepsis. "

Related Drugs and Biologics

1.	Selenium
2.	Glutathione Peroxidase
3.	Selenoproteins (Selenoprotein)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Diquat
6.	Peroxynitrous Acid (Peroxynitrite)
7.	Oxygen (Dioxygen)
8.	Nitrogen
9.	Halogens
10.	Carrageenan

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy
3.	Lasers (Laser)
4.	Critical Care (Surgical Intensive Care)