Abstract |
Objective: To study the relationship between the intracardiac echogenic foci and the abnormal chromosome and the changes of Cardiac function. Methods: A total of 2645 cases with the gestational age between 14 to 22 weeks were tested in the department of gynecology and obstetrics of the Second Hospital of Jilin University from Jan.2016 to Dec.2017.Seventy-nine of them existed the intracardiac echogenic foci, and the patient's imaging data in details were recorded.All of them have taken the non-invasive DNA examination.Fetal echocardiography was performed at 22-24 weeks.Karyotype analysis was performed using amniocentesis and umbilical cord blood puncture.Inducing labor was performed for fetuses that has been identified as a haploid or had a severely malformation during pregnancy.The other fetuses were followed up to the birth.Echocardiography was performed on neonates. Results: The detection rate of intracardiac echogenic focus was 3.0% in early pregnancy, 92% in the left ventricle, 4% in the right ventricle, and 4% in double ventricle.There were 5 cases of haploid fetus induced labor, 2 cases of induced labor due to fatal malformation.Fetal echocardiography revealed tricuspid regurgitation in 7 cases.One of them was induced labor in consideration of heart failure. Conclusions: 1.The risk of chromosomal abnormality in the fetus of isolated left intracardiac echogenic focus is lower.Non-invasive DNA examination has a high reliability that could be an important reference before an invasive antenatal diagnosis.2.A higher rate of fetal malformation will be found when the foci located in the right or double ventricle.3.The relationship between fetal intracardiac echogenic foci and fetal cardiac dysfunction needs to be further clarified.
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Authors | M Wei, J Zhang, Z Y Liu, R Q Yang, Q Q Yu, F Wang, L M Fan, Y Nan |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 98
Issue 47
Pg. 3864-3867
(Dec 18 2018)
ISSN: 0376-2491 [Print] China |
PMID | 30585031
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Chromosomes, Human
- Female
- Fetus
- Heart
- Humans
- Infant, Newborn
- Pregnancy
- Reproducibility of Results
- Ultrasonography, Prenatal
- Young Adult
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