Vitamin E - The Next 100 Years.

Abstract

α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low-grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Vitamin E and some of its metabolites modulate cell signaling and gene transcription. Future research is needed to achieve a better understanding of the molecular events leading to gene regulation by vitamin E, especially in its phosphorylated form. Isolation and characterization of the vitamin E kinase and vitamin E phosphate phosphatase will help in the understanding of cell regulation processes modulated by vitamin E. A clarification of the pathogenesis of AVED remains an important goal to be achieved. © 2018 IUBMB Life, 71(4):411-415, 2019.

• Authors: Fatemeh Khadangi, Angelo Azzi
• Journal: IUBMB life (IUBMB Life) Vol. 71 Issue 4 Pg. 411-415 (04 2019) ISSN: 1521-6551 [Electronic] England
• PMID: 30550633 (Publication Type: Journal Article, Review)
• Copyright: © 2018 International Union of Biochemistry and Molecular Biology.

Chemical References

• Antioxidants
• Vitamin E
• alpha-Tocopherol

Topics

• Animals
• Antioxidants (metabolism)
• Humans
• Neurodegenerative Diseases (prevention & control)
• Vitamin E (pharmacology, physiology)
• Vitamin E Deficiency (etiology, prevention & control)
• alpha-Tocopherol (pharmacology)