Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling.

Abstract

Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids (TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid (SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription (STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.

• Authors: Juan Chen, Jia Yue, Jiao Liu, Yun Liu, Kai-Lin Jiao, Meng-Ying Teng, Chun-Yan Hu, Jing Zhen, Mao-Xuan Wu, Ming Zhou, Zhong Li, Yuan Li
• Journal: Chinese journal of natural medicines (Chin J Nat Med) Vol. 16 Issue 11 Pg. 838-845 (Nov 2018) ISSN: 1875-5364 [Electronic] China
• PMID: 30502765 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Chemical References

• Alkenes
• Drugs, Chinese Herbal
• Polyphenols
• STAT3 Transcription Factor
• Sterol Regulatory Element Binding Protein 1
• Triglycerides
• salvianolic acid

Topics

• Alkenes (administration & dosage)
• Animals
• Drugs, Chinese Herbal (administration & dosage)
• Female
• Humans
• Lipid Metabolism (drug effects)
• Liver (drug effects, metabolism)
• Obesity (drug therapy, genetics, metabolism)
• Ovariectomy
• Polyphenols (administration & dosage)
• Postmenopause (drug effects, genetics, metabolism)
• Rats
• STAT3 Transcription Factor (genetics, metabolism)
• Salvia miltiorrhiza (chemistry)
• Signal Transduction (drug effects)
• Sterol Regulatory Element Binding Protein 1 (genetics, metabolism)
• Triglycerides (metabolism)