Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats.

Abstract

One of the major consequences of diabetes is reproductive dysfunction but the fundamental mechanisms are still poorly known. The objective of the present study was to explore the beneficial role of taurine against streptozotocin induced testicular dysfunctions in diabetic male Wister rats and understanding the underlying intricate molecular mechanisms. Exposure to streptozotocin (50 mg kg-1 body weight, i.p., once) elevated blood glucose level, induced testicular histological alterations and reduced testis-to-body weight ratio, serum testosterone, testicular markers and activity of antioxidant enzymes. Generation of ER stress (increased expression of calpain-1, caspase-12 and upregulation of CHOP, GRP78 via eIF2α signaling), translocation of NF κB in the nucleus (leading to the upregulation in the levels of inflammatory cytokines), activation of mitochondria dependent apoptotic pathway and DNA fragmentation were revealed from this study. However, administration of taurine at a dose of 100 mg kg-1 body weight for 6 weeks post diabetic induction, successfully ameliorated all these adverse effects. Thus, taurine, as a potential therapeutic agent, may hold promise in preventing oxidative and ER stress mediated diabetic testicular complications in rats.

• Authors: Sumit Ghosh, Sayantani Chowdhury, Abhishek Kumar Das, Parames C Sil
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 124 Pg. 64-80 (Feb 2019) ISSN: 1873-6351 [Electronic] England
• PMID: 30496779 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Biomarkers
• Chemokines
• Taurine
• Streptozocin
• Oxidoreductases
• Catalase

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antioxidants (therapeutic use)
• Apoptosis (drug effects)
• Biomarkers (metabolism)
• Catalase (metabolism)
• Chemokines (metabolism)
• Diabetes Mellitus, Experimental (chemically induced, complications)
• Endoplasmic Reticulum Stress (drug effects)
• Hyperglycemia (complications)
• Inflammation (drug therapy, etiology)
• Male
• Oxidative Stress (drug effects)
• Oxidoreductases (metabolism)
• Rats, Wistar
• Signal Transduction (drug effects)
• Streptozocin
• Taurine (therapeutic use)
• Testicular Diseases (etiology, prevention & control)
• Testis (enzymology, pathology)