Immunoglobulin G subclass 3 in ISN/RPL lupus nephritis classification
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Abstract

OBJECTIVES:

In lupus nephritis, the immune complex plays a very important role in kidney disease progression, and immunoglobulin G subclass 3 (IgG3) may play an important role in endothelial damage as lupus nephropathy progresses. We evaluated the association between IgG3 positivity and lupus nephritis activity.

MATERIALS AND METHODS:

We identified 71 biopsies taken from 57 patients who had lupus nephritis with enough tissue to allow light and immunofluorescence microscopy. We compared the intensity of IgG subclass staining (on a scale of 0 - 3+) with IgG subclass dominance among lupus nephritis classes as defined by the ISN/RPS 2003 classification.

RESULTS:

The proportion of IgG3-positive patients with capillary loop lesion was significantly higher in the class IV group compared with other groups (p < 0.01). Interestingly, in most patients IgG1 was the strongest subclass; in class IV groups, IgG3 was the strongest in 21% of the biopsies. IgG3 deposition in capillary loops was significantly associated with C1q deposition in those loops. According to Kaplan-Meier analysis, renal survival rates in the patients with IgG3 deposition was lower (82.2%) than in patients without IgG3 deposition (93.3%), but the difference was not significant.

CONCLUSION:

Our results suggest that capillary loop deposition of IgG3 is associated with disease activity in lupus nephritis.
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• Authors: Junko Yabuuchi, Junichi Hoshino, Hiroki Mizuno, Yuko Ozawa, Akinari Sekine, Masahiro Kawada, Keiichi Sumida, Rikako Hiramatsu, Noriko Hayami, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Naoki Sawa, Takeshi Fujii, Kenichi Ohashi, Kenmei Takaichi, Yoshifumi Ubara
• Journal: Clinical nephrology (Clin Nephrol) Vol. 91 Issue 1 Pg. 32-39 (Jan 2019) ISSN: 0301-0430 [Print] Germany
• PMID: 30431429 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin G

Topics

• Adult
• Female
• Fluorescent Antibody Technique
• Humans
• Immunoglobulin G (immunology)
• Kidney (pathology)
• Lupus Nephritis (immunology, pathology)
• Male
• Middle Aged
• Retrospective Studies
• Survival Analysis