The aim of the present research was to Study the prevention of
dyslipidemia, oxidative stress,
inflammation and
fatty liver as risk factors for cardiovascular disease via intervention by
borage oil (B) and
fish oil (F) with or without turmeric (T) and alpha-
tocopherols (TC).
Fatty acids were assessed in both
oils while
curcuminoids were determined in turmeric. Rats were divided into; first group fed on balanced diet and designated as normal control (NC), second fed on dyslipidemic and
steatohepatitis (DS) inducer diet which represented the DS control group and groups 3-6 fed on DS inducer diet with daily
oral administration of B, B+T+TC, F and F+T+TC; respectively for 5 weeks. Liver fat and plasma
lipid profile, oxidative stress and inflammatory
biomarker and liver and heart histopathology were assessed. Results showed gamma linolenic to be 21.01% in B. F contained eicosapentaenoic as 22.768% and
docosahexaenoic acid as 13.574%.Total
curcuminoids were 4.63 mg/g turmeric. The DS control group showed significant
dyslipidemia, elevated
malondialdehyde (MDA),
tumor necrosis factor-alpha and liver fat with significant reduction in total
antioxidant capacity (TAC) compared to NC. The different treatments produced significant improvement in all the parameters and histopathology. F was superior to B in ameliorating liver histopathological changes while B was more efficient in elevating TAC. B was more promising in improving
lipid profile and liver fat compared to B + T + TC, while the latter was superior in improving MDA and liver histopathology.
Fish oil was more efficient than F+TC+T except for TAC and
high density lipoprotein cholesterol which were more improved on addition of TC and T. Conclusion: Borage and
fish oil with or without
antioxidants protect from cardiovascular and
fatty liver diseases with variable degrees.