The comprehensive outcomes of hepatitis C virus infection: A multi-faceted chronic disease.

Abstract

Treatment of hepatitis C virus (HCV) infection has been revolutionized with the introduction of pangenotypic, interferon- and ribavirin-free regimens associated with high cure rates and a low side effect profile. Additionally, there is evidence that HCV cure reduces HCV complications, improves patient-reported outcomes and is cost-saving in most western countries in the long term. This is a review of the comprehensive burden of HCV and the value of eliminating HCV infection. With the introduction of the interferon-free all-oral, once a day pill treatment regimen for the cure of HCV, the potential to eliminate HCV by 2030 has become a possibility for some regions of the world. Nevertheless, there are barriers to screening, linkage to care, and treatment in many countries that must be overcome in order to reach this goal. In conclusion, globally, work must continue to ensure national policies are in place to support screening, linkage to care and affordable treatment in order to eliminate HCV.

• Authors: Zobair Younossi, Georgios Papatheodoridis, Patrice Cacoub, Francesco Negro, Heiner Wedemeyer, Linda Henry, Angelos Hatzakis
• Journal: Journal of viral hepatitis (J Viral Hepat) Vol. 25 Suppl 3 Pg. 6-14 (11 2018) ISSN: 1365-2893 [Electronic] England
• PMID: 30398294 (Publication Type: Journal Article, Review)
• Copyright: © 2018 The Authors. Journal of Viral Hepatitis Published by John Wiley & Sons Ltd.

Chemical References

• Antiviral Agents

Topics

• Administration, Oral
• Antiviral Agents (administration & dosage, economics)
• Disease Eradication
• Global Health
• Health Care Costs
• Health Policy
• Hepatitis C, Chronic (diagnosis, drug therapy, epidemiology)
• Humans
• Mass Screening (organization & administration)
• Treatment Outcome