Renal effects of sodium glucose co-transporter 2 inhibitors in Japanese type 2 diabetes mellitus patients with home blood pressure monitoring.

Abstract

Decrease in blood pressure contributes to the reno-protective effects of sodium-glucose cotransporter 2 inhibitors; however, its relationship with home monitoring of blood pressure is unclear. We retrospectively analyzed 101 visiting members of the Kanagawa Physicians Association with type 2 diabetes mellitus and chronic kidney disease who were taking sodium-glucose cotransporter 2 inhibitors and who monitored blood pressure at home for a median treatment period of 14 months. At baseline, the mean value of HbA1c was 59.3 mmol/mol (7.6%) and the median value of albumin-creatinine ratio was 30.9 mg/gCr that was evaluated in 88 patients. The mean blood pressure both at office and home significantly decreased, and there was a significant positive correlation between the change in albumin-creatinine ratio and both blood pressures. Controlled hypertension, masked hypertension, white coat hypertension, and sustained hypertension were observed in 10.9%, 13.9%, 12.9%, and 62.4% of patients at the initiation of therapy, which changed to 10.9%, 16.8%, 17.8%, and 54.5% at the time of the survey, respectively. In conclusion, management of blood pressure both at office and home was found to be important for the reno-protective effects of sodium-glucose cotransporter 2 inhibitors along with strict blood pressure management.

• Authors: Kazuo Kobayashi, Masao Toyoda, Moritsugu Kimura, Nobuo Hatori, Takayuki Furuki, Hiroyuki Sakai, Masahiro Takihata, Tomoya Umezono, Shun Ito, Daisuke Suzuki, Hiroshi Takeda, Akira Kanamori, Hisakazu Degawa, Hareaki Yamamoto, Hideo Machimura, Atsuko Mokubo, Keiichi Chin, Mitsuo Obana, Toshimasa Hishiki, Kouta Aoyama, Shinichi Nakajima, Shinichi Umezawa, Hidetoshi Shimura, Togo Aoyama, Kazuyoshi Sato, Masaaki Miyakawa
• Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) (Clin Exp Hypertens) Vol. 41 Issue 7 Pg. 637-644 ( 2019) ISSN: 1525-6006 [Electronic] England
• PMID: 30373408 (Publication Type: Journal Article)

Chemical References

• Glycated Hemoglobin A
• Hypoglycemic Agents
• Serum Albumin
• Sodium-Glucose Transporter 2 Inhibitors
• hemoglobin A1c protein, human
• Creatinine

Topics

• Adult
• Aged
• Aged, 80 and over
• Blood Pressure (drug effects)
• Blood Pressure Monitoring, Ambulatory
• Creatinine (blood)
• Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Hypertension (complications, physiopathology)
• Hypertension, Renal (etiology, physiopathology)
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Japan
• Kidney (physiopathology)
• Male
• Masked Hypertension (complications, physiopathology)
• Middle Aged
• Renal Insufficiency, Chronic (complications, physiopathology)
• Retrospective Studies
• Serum Albumin (metabolism)
• Sodium-Glucose Transporter 2 Inhibitors (pharmacology, therapeutic use)
• White Coat Hypertension (complications, physiopathology)