Abstract | PURPOSE: METHODS: Methods: This prospective single-center hospital-based case-control study included 33 patients with metastatic UBC treated with cisplatin-based chemotherapy and 227 healthy controls. GPX1 SNP (rs1050450) was assessed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and SOD2 SNP (rs4880) was determined by quantitative PCR (q-PCR). Overall survival (OS) was evaluated using Kaplan–Meier survival analysis during 2-year follow up period, with the log-rank test for prognostic significance. RESULTS: Results: No significant difference was observed in the distributions of GPX1 and SOD2 gene variants between patients and controls (p˃0.05). Regarding GPX1 polymorphism, no impact of GPX1 polymorphism on OS could be demonstrated (p˃0.05). Finally, Kaplan-Meier survival analysis showed no association between SOD2 polymorphism and OS (p˃0.05). CONCLUSIONS: Conclusions: No association was found between polymorphism of GPX1 and SOD2 and OS in patients with metastatic urothelial bladder cancer treated with cisplatin-based chemotherapy.
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Authors | Predrag Nikic, Degan Dragicevic, Ana Savic-Radojevic, Marija Pljesa-Ercegovac, Vesna Coric, Djurdja Jovanovic, Uros Bumbasirevic, Tatjana Pekmezovic, Tatjana Simic, Zoran Dzamic, Marija Matic |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2018 Jul-Aug
Vol. 23
Issue 4
Pg. 1130-1135
ISSN: 1107-0625 [Print] Cyprus |
PMID | 30358222
(Publication Type: Journal Article)
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Chemical References |
- Glutathione Peroxidase
- Superoxide Dismutase
- superoxide dismutase 2
- Cisplatin
- Glutathione Peroxidase GPX1
- GPX1 protein, human
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Case-Control Studies
- Cisplatin
(administration & dosage)
- Female
- Glutathione Peroxidase
(genetics)
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- Polymorphism, Single Nucleotide
- Prospective Studies
- Serbia
(epidemiology)
- Superoxide Dismutase
(genetics)
- Survival Analysis
- Urinary Bladder Neoplasms
(drug therapy, enzymology, genetics, mortality)
- Glutathione Peroxidase GPX1
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