Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia.

Abstract

Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7-9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

• Authors: Benjamin Ole Wolthers, Pernille R Mogensen, Thomas L Frandsen, Jonas Abrahamsson, Mikael Behrendtz, Mats Heyman, Olli Lohi, Ulrika Norén-Nyström, Ellen Ruud, Kjeld Schmiegelow
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 66 Issue 1 Pg. e27437 (01 2019) ISSN: 1545-5017 [Electronic] United States
• PMID: 30216644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents
• Asparaginase

Topics

• Acute Disease
• Adolescent
• Antineoplastic Agents (adverse effects)
• Asparaginase (adverse effects)
• Child
• Child, Preschool
• Diabetes Mellitus, Type 1 (etiology, pathology)
• Female
• Follow-Up Studies
• Humans
• Infant
• Male
• Pancreatitis (chemically induced, complications, pathology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, physiopathology)
• Prognosis