Abstract | BACKGROUND: METHODS: RESULTS: Over a median follow-up period of 21.1 months, the primary end point occurred in 626 (25.0%) of 2507 patients assigned to rivaroxaban and in 658 (26.2%) of 2515 patients assigned to placebo (hazard ratio, 0.94; 95% confidence interval [CI], 0.84 to 1.05; P=0.27). No significant difference in all-cause mortality was noted between the rivaroxaban group and the placebo group (21.8% and 22.1%, respectively; hazard ratio, 0.98; 95% CI, 0.87 to 1.10). The principal safety outcome occurred in 18 patients who took rivaroxaban and in 23 who took placebo (hazard ratio, 0.80; 95% CI, 0.43 to 1.49; P=0.48). CONCLUSIONS:
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Authors | Faiez Zannad, Stefan D Anker, William M Byra, John G F Cleland, Min Fu, Mihai Gheorghiade, Carolyn S P Lam, Mandeep R Mehra, James D Neaton, Christopher C Nessel, Theodore E Spiro, Dirk J van Veldhuisen, Barry Greenberg, COMMANDER HF Investigators |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 379
Issue 14
Pg. 1332-1342
(10 04 2018)
ISSN: 1533-4406 [Electronic] United States |
PMID | 30146935
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Factor Xa Inhibitors
- Platelet Aggregation Inhibitors
- Natriuretic Peptide, Brain
- Rivaroxaban
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Topics |
- Aged
- Coronary Artery Disease
(complications, drug therapy)
- Double-Blind Method
- Drug Therapy, Combination
- Factor Xa Inhibitors
(adverse effects, therapeutic use)
- Female
- Follow-Up Studies
- Heart Failure
(complications, drug therapy, mortality, physiopathology)
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, prevention & control)
- Natriuretic Peptide, Brain
(blood)
- Patient Readmission
(statistics & numerical data)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Rivaroxaban
(adverse effects, therapeutic use)
- Stroke
(epidemiology, prevention & control)
- Stroke Volume
- Treatment Failure
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