Evaluation of the Performance of a Nature-Based Sensitive Skin Regimen in Subjects With Clinically Diagnosed Sensitive Skin.

Abstract

BACKGROUND:

Unique whole formula nature-based sensitive skin products are formulated to minimize irritation while providing conditioning and soothing benefits to clinically diagnosed sensitive skin.

OBJECTIVE:

To evaluate and compare the efficacy and tolerability of a regimen of cleanser containing natural oils, beeswax, and witch hazel, and day & night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol, sodium lauryl sulphate-containing cleanser and glycerin, polyisobutene-containing lotion (CR) in clinically diagnosed sensitive skin resulting from eczema/atopic dermatitis, rosacea, or cosmetic intolerance.

METHODS:

120 subjects were randomized to receive either NR or CR, twice daily for 4 weeks in this double-blind study. Blinded investigator-rated and subject-rated overall skin appearance was assessed using a 5-point scale (0=none, 4=severe) at baseline, 2 weeks, and 4 weeks. Noninvasive skin assessments for skin hydration and skin barrier function were made by corneometry and TEWL, respectively.

RESULTS:

NR resulted in a 34% improvement from baseline in investigator-rated overall skin appearance (P less than 0.001); and CR resulted in a 4% improvement. Similar NR and CR results were found in the other efficacy parameters: tactile and visual smoothness, clarity, and radiance. Both regimens improved barrier function from baseline to week 4 (17%, 15%; NR, CR, P equals NS). NR maintained hydration from baseline to week 4 while CR increased hydration by 21% (P less than 0.001). No clinically significant tolerability issues were reported in either regimen at week 4.

CONCLUSIONS:

The study demonstrated that NR was effective, well tolerated, and superior to CR in the management of sensitive skin. J Drugs Dermatol. 2018;17(8):908-913.

• Authors: Zoe Diana Draelos, Stanley B Levy, Celeste Lutrario, Hemali Gunt
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 17 Issue 8 Pg. 908-913 (Aug 01 2018) ISSN: 1545-9616 [Print] United States
• PMID: 30124733 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biological Products
• Dermatologic Agents

Topics

• Administration, Topical
• Adult
• Biological Products (administration & dosage, adverse effects)
• Dermatitis, Atopic (diagnosis, drug therapy)
• Dermatologic Agents (administration & dosage, adverse effects)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Pruritus (chemically induced, diagnosis)
• Skin Care (methods)
• Treatment Outcome
• Young Adult