Rosacea (Acne Rosacea)

Subscribe to Selected New Research on Rosacea

555 relevant articles (96 outcomes, 89 trials/studies) found for this Disease

Description: A cutaneous disorder primarily of convexities of the central part of the FACE, such as FOREHEAD; CHEEK; NOSE; and CHIN. It is characterized by FLUSHING; ERYTHEMA; EDEMA; RHINOPHYMA; papules; and ocular symptoms. It may occur at any age but typically after age 30. There are various subtypes of rosacea: erythematotelangiectatic, papulopustular, phymatous, and ocular (National Rosacea Society's Expert Committee on the Classification and Staging of Rosacea, J Am Acad Dermatol 2002; 46:584-7).

Also Known As:

Acne Rosacea; Granulomatous Rosacea; Ocular Rosacea; Erythematotelangiectatic Rosacea; Papulopustular Rosacea; Phymatous Rosacea; Rosacea, Erythematotelangiectatic; Rosacea, Granulomatous; Rosacea, Ocular; Rosacea, Papulopustular; Rosacea, Phymatous

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 5944

Rosacea: 555

Rhinophyma: 102

Related Diseases

1.	Acne Vulgaris
2.	Erythema
3.	Rosacea (Acne Rosacea)
4.	Dermatitis
5.	Perioral Dermatitis

Experts

1.	Del Rosso, James Q: 8 articles (06/2008 - 01/2004)
2.	Fleischer, Alan B: 4 articles (06/2008 - 11/2003)
3.	Draelos, Zoe Diana: 4 articles (11/2006 - 10/2004)
4.	Elewski, Boni E: 3 articles (01/2007 - 11/2003)
5.	Wolf, John E: 3 articles (01/2007 - 01/2004)
6.	Thiboutot, Diane: 3 articles (11/2006 - 06/2003)
7.	Graupe, Klaus: 2 articles (06/2008 - 06/2003)
8.	Powell, F C: 2 articles (05/2008 - 09/2007)
9.	Piérard, Gérald E: 2 articles (03/2008 - 01/2003)
10.	Bradshaw, Mark: 2 articles (09/2007 - 11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rosacea:

1.	Metronidazole (Metric)FDA LinkGeneric 08/01/2007 - "The remarkable clinical efficacy of metronidazole in the treatment of rosacea is probably due to its ability to decrease ROS via different mechanisms, thereby protecting skin components from induced damage." 05/01/2000 - "CONCLUSIONS: Topical metronidazole formulations are significantly more effective than placebo when used in the initial treatment of patients with moderate to severe rosacea" 05/01/2000 - "Metronidazole preparations (0.75 and 1% cream, 0.75% gel and 0.75% lotion) were significantly more effective than placebo in patients with moderate to severe rosacea when administered to the affected area once or twice daily for 7 to 12 weeks" 11/01/2001 - "BACKGROUND: The papules and pustules of rosacea can be effectively treated with topical metronidazole" 05/01/2000 - "Topical application of the antibacterial agent metronidazole is effective in the treatment of moderate to severe rosacea, although its mechanism of action has yet to be clearly established" Order ALL the reference details at left...
2.	azelaic acid (Azelex)FDA Link 10/01/2008 - "There are several topical and oral treatments available, of which azelaic acid 15% gel (Finacea) is the first new treatment for rosacea in more than a decade" 10/01/2008 - "Clinical studies have shown that azelaic acid 15% gel is an effective and safe first-line topical therapeutic option in patients with mild-to-moderate papulopustular rosacea" 06/01/2008 - "BACKGROUND: Twice-daily azelaic acid (AzA) is the conventional regimen for papulopustular rosacea, but once-daily AzA may be equally effective, with greater convenience and dosing flexibility" 02/01/2006 - "Azelaic acid (AzA) initially was released in a 20% cream formulation, which has been shown to be effective in the treatment of mild to moderate rosacea" 01/01/2004 - "Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties" Order ALL the reference details at left...
3.	Doxycycline (Vibramycin)FDA LinkGeneric 07/01/2007 - "Is low-dose doxycycline effective for rosacea?" 05/01/2007 - "CONCLUSION: Once-daily anti-inflammatory dose doxycycline appears to be effective and safe for the treatment of rosacea." 05/01/2007 - "BACKGROUND: Doxycycline monotherapy at antimicrobial doses has been shown to be effective for the treatment of rosacea" 09/01/2007 - "BACKGROUND: Two large clinical trials have recently demonstrated the efficacy of a 40-mg controlled-release formulation of doxycycline in the treatment of rosacea, a dose well below the conventional level of 100 to 200 mg/d" 06/01/2007 - "Phase III studies have substantiated the efficacy of anti-inflammatory dose doxycycline (40-mg doxycycline monohydrate controlled-release capsules) administered once daily for the treatment of inflammatory lesions of rosacea" Order ALL the reference details at left...
4.	pimecrolimus (Elidel)FDA Link 04/01/2007 - "Steroid-aggravated rosacea: successful therapy with pimecrolimus]" 05/01/2008 - "CONCLUSIONS: This study suggests that pimecrolimus 1% cream is an effective and well-tolerated treatment for steroid-induced rosacea." 01/01/2006 - "Pimecrolimus cream 1% is effective in a case of granulomatous rosacea." 04/01/2007 - "An open-label pilot study to evaluate the safety and efficacy of topically applied pimecrolimus cream for the treatment of steroid-induced rosacea-like eruption." 06/01/2008 - "We believe further studies with topical pimecrolimus cream on larger study groups with different subtypes and severity of rosacea will clarify the potential effect of pimecrolimus cream for the treatment of rosacea." Order ALL the reference details at left...
5.	Tacrolimus (Prograf)FDA Link 01/01/2004 - "Twenty-four patients with erythrotelangiectatic or papulopustular rosacea were treated with 0.1% tacrolimus topical ointment in a 12-week open-label trial" 01/01/2004 - "Tacrolimus effect on rosacea." 06/01/2001 - "METHODS: Three patients with steroid-induced rosacea applied tacrolimus ointment, 0.075% twice daily for 7 to 10 days" 06/01/2001 - "OBJECTIVE: The purpose of this article is to review the use of tacrolimus ointment, a macrolide anti-inflammatory ointment for the treatment of 3 patients with steroid-induced rosacea" 06/01/2001 - "Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report." Order ALL the reference details at left...
6.	Tetracycline (Achromycin)FDA LinkGeneric 08/01/1978 - "Eighteen patients with ocular rosacea were treated with oral tetracycline which resulted in marked improvement in all patients" 03/01/1995 - "The effects of tetracycline and meibomian gland expression therapy also were investigated in patients with ocular rosacea" 03/01/1993 - "Mite counts in patients with rosacea before and after a 1-month course of oral tetracycline showed no significant difference" 05/15/1985 - "Treatment of active ocular rosacea with tetracycline for one month had no effect on tear pH in six patients." 01/01/1983 - "A 40-year-old woman with rosacea had been treated with tetracycline-hydrochloride (Achromycin) 250 mg daily for 3 years" Order ALL the reference details at left...
7.	Isotretinoin (Accutane)FDA LinkGeneric 12/01/1986 - "At the end of the study period, isotretinoin was found to be highly effective in the clearing of refractory rosacea lesions." 03/05/1982 - "13-cis-retinoic acid was given with good results to 7 patients with exceptionally severe rosacea" 07/01/1998 - "Efficacy of low-dose isotretinoin in patients with treatment-resistant rosacea." 03/01/2004 - "Continuous 'microdose' isotretinoin in adult recalcitrant rosacea." 12/15/1995 - "The oral treatment of rosacea with isotretinoin]" Order ALL the reference details at left...
8.	Azithromycin (Zithromax)FDA LinkGeneric 02/01/2007 - "Nine of 10 subjects treated with azithromycin showed moderate to marked improvement of their acne rosacea" 09/01/2004 - "Azithromycin was not as effective for the treatment of rosacea" 03/01/2007 - "The results of our study support the antioxidant properties of azithromycin in rosacea." 03/01/2007 - "AIM: We planned a study to evaluate the antioxidant effects of azithromycin on ROS in rosacea" 02/01/2004 - "We planned a study to evaluate the efficacy and safety of azithromycin in rosacea" Order ALL the reference details at left...
9.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2007 - "Selective antibiotics are effective in reducing the inflammatory changes of papulopustular rosacea, but their mode of action is unknown" 11/01/1988 - "Topical antibiotics are safe and effective in certain conditions, primarily acne, rosacea, and nasal carriage of Staphylococcus aureus" 03/01/2008 - "Systemic antibiotics currently used in the treatment of rosacea are sometimes associated with uncomfortable side effects" 08/01/2007 - "We present a case of rosacea that was unresponsive to treatment with antibiotics" 06/01/2007 - "Certain antibiotics that can inhibit P acnes colonization also have demonstrated anti-inflammatory activities in the treatment of acne, rosacea, and other noninfectious diseases" Order ALL the reference details at left...
10.	TetracyclinesIBA 01/01/2004 - "PURPOSE: To review the basis for the use of oral tetracyclines in ocular rosacea" 01/01/2004 - "Oral tetracyclines for ocular rosacea: an evidence-based review of the literature." 01/01/1989 - "A good therapeutic response of "rosacea-like eruptions" to tetracyclines could possibly confirm the authors' hypothesis." 01/01/1969 - "Tetracyclines in the treatment of ocular rosacea." 03/01/2004 - "The treatment with oral tetracyclines significantly improved the state of ocular rosacea in four patients, while in one case the changes of the anterior eye segment progressed in more severe state of ulcerative keratitis" Order ALL the reference details at left...

Therapies and Procedures

1.	Dye Lasers 06/01/2004 - "We conclude that pulsed dye laser therapy is a useful treatment for rosacea." 04/01/2008 - "STUDY DESIGN/MATERIALS AND METHODS: Twenty subjects with rosacea were treated with the high-energy, long pulse-duration pulsed-dye laser" 04/01/2008 - "In this study we investigate the ability of the long pulse-duration pulsed-dye laser to improve rosacea" 04/01/2008 - "The pulsed-dye laser has an unparalleled safety record and emits an ideal wavelength for treating the abnormal vessels that occur in rosacea patients" 04/01/2008 - "Rosacea treatment using the new-generation, high-energy, 595 nm, long pulse-duration pulsed-dye laser." Order ALL the reference details at left...
2.	Lasers (Laser) 03/01/2005 - "Despite the increased use of lasers and other light-based therapies, few well-controlled studies have been conducted on their use for the treatment of rosacea" 11/01/2004 - "Laser treatment of rosacea: a pathoetiological study." 08/01/2007 - "We report the novel use of a new laser technology, the multiplexed laser, for treatment of both papular and telangiectatic rosacea." 11/01/2005 - "Newer technologies, namely medical lasers and light sources, have made it possible to control and improve erythematotelangietatic signs of rosacea" 03/01/2005 - "However, monochromatic (i.e., laser) and polychromatic light-based therapies are increasingly being used for the treatment of certain signs of rosacea" Order ALL the reference details at left...
3.	Aftercare (After-Treatment) 04/01/2007 - "The mean level of the L()a()b() values improved significantly after treatment and particularly in the erythematotelangiectatic rosacea patients" 07/01/2008 - "Two dermatologists, unblinded on therapy, evaluated rosacea patients before and after treatment on the basis of an objective scale" 03/01/1999 - "The severity of rosacea was scored before and after treatment" 01/01/1995 - "pylori isolates and serology after treatment was an additional evidence suggesting an etiologic relationship between rosacea and H" 01/01/1981 - "2 patients with rosacea and 4 patients with perioral dermatitis relapsed, but cleared again after treatment was repeated" Order ALL the reference details at left...*
4.	Homologous Transplantation (Allograft) 01/01/2002 - "It has also been suggested that topical tacrolimus is useful in the treatment of alopecia areata, erosive lichen planus, isolated ichthyosis linearis circumflexa, steroid-induced rosacea, and in the prevention of allograft rejection, however more clinical trials need to be performed." Order ALL the reference details at left...
5.	Skin Care 09/01/2006 - "DISCUSSION: The skin care regimen containing Lic A was found to be compatible with the sensitive facial skin of patients with rosacea and improved the appearance of persistent facial redness" 01/01/2007 - "CONCLUSIONS: It can thus be concluded that in the management of rosacea, basic skin care regimens, including daily use of a therapeutic moisturizer, offer optimal benefits." 11/01/2006 - "In a roundtable discussion, information leaders discussed the pathophysiology of rosacea and other issues of importance to successful rosacea management, such as skin care regimens, quality of life (QOL), and compliance." 04/01/2006 - "A good skin care regimen is a critical part of rosacea treatment; however, care must be taken to choose nonirritating products because individuals with rosacea tend to have sensitive skin, and irritants can trigger a worsening of symptoms" 09/01/2005 - "Accordingly, the management of rosacea involves not only choosing appropriate medication and treatment for daily skin care, but also avoiding known trigger factors" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Rosacea

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 96 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>