Range of L5 LDL levels in healthy adults and L5's predictive power in patients with hyperlipidemia or coronary artery disease.

Abstract

Electronegative L5 low-density lipoprotein (LDL) level may be a useful biomarker for predicting cardiovascular disease. We determined the range of plasma L5 levels in healthy adults (n = 35) and examined the power of L5 levels to differentiate patients with coronary artery disease (CAD; n = 40) or patients with hyperlipidemia (HLP) without evidence of CAD (n = 35) from healthy adults. The percent L5 in total LDL (L5%) was quantified by using fast-protein liquid chromatography with an anion-exchange column. Receiver operating characteristic curve analysis was performed to determine cut-off values for L5 levels. The mean L5% and plasma concentration of L5 (ie, [L5]) were significantly higher in patients with HLP or CAD than in healthy adults (P < 0.001). The ranges of L5% and [L5] in healthy adults were determined to be <1.6% and <1.7 mg/dL, respectively. In individuals with L5% >1.6%, the odds ratio was 9.636 for HLP or CAD. In individuals with [L5] >1.7 mg/dL, the odds ratio was 17.684 for HLP or CAD. The power of L5% or [L5] to differentiate patients with HLP or CAD from healthy adults was superior to that of the LDL/high-density lipoprotein ratio. The ranges of L5% and [L5] in healthy adults determined here may be clinically useful in preventing and treating cardiovascular disease.

• Authors: Chih-Sheng Chu, Hua-Chen Chan, Ming-Hsien Tsai, Nicole Stancel, Hsiang-Chun Lee, Kai-Hung Cheng, Yi-Ching Tung, Hsiu-Chuan Chan, Chung-Ya Wang, Shyi-Jang Shin, Wen-Ter Lai, Chao-Yuh Yang, Richard A Dixon, Chu-Huang Chen, Liang-Yin Ke
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 11866 (08 08 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30089847 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Lipoproteins, LDL
• oxidized low density lipoprotein

Topics

• Adult
• Coronary Artery Disease (blood, etiology)
• Female
• Humans
• Hyperlipidemias (blood, complications)
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Odds Ratio
• Risk Factors