Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression.

Abstract

OBJECTIVE:

This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression.

METHODS:

This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers.

RESULTS:

Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters.

CONCLUSION:

The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.

• Authors: Bruna Panizzutti, Chiara Bortolasci, Kyoko Hasebe, Srisaiyini Kidnapillai, Laura Gray, Ken Walder, Michael Berk, Mohammadreza Mohebbi, Seetal Dodd, Clarissa Gama, Pedro V Magalhães, Susan M Cotton, Flávio Kapczinski, Ashley I Bush, Gin S Malhi, Olivia M Dean
• Journal: Acta neuropsychiatrica (Acta Neuropsychiatr) Vol. 30 Issue 6 Pg. 334-341 (Dec 2018) ISSN: 1601-5215 [Electronic] England
• PMID: 30008280 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Brain-Derived Neurotrophic Factor
• Interleukins
• TNF protein, human
• Tumor Necrosis Factor-alpha
• BDNF protein, human
• C-Reactive Protein
• Acetylcysteine

Topics

• Acetylcysteine (therapeutic use)
• Adult
• Aged
• Bipolar Disorder (blood, complications, drug therapy)
• Brain-Derived Neurotrophic Factor (blood)
• C-Reactive Protein (metabolism)
• Encephalitis (blood, complications)
• Female
• Humans
• Interleukins (blood)
• Male
• Middle Aged
• Neurogenesis
• Treatment Outcome
• Tumor Necrosis Factor-alpha (blood)
• Young Adult