Prevalence and associated knowledge of hepatitis B infection among healthcare workers in Freetown, Sierra Leone.

Abstract

BACKGROUND:

Hepatitis B virus (HBV) is considered highly prevalent in West Africa. However, major gaps in surveillance exist in Sierra Leone. Although healthcare workers (HCWs) are at high risk for HBV infection, little is known about the prevalence and knowledge of hepatitis B among HCWs in Sierra Leone.

METHODS:

A cross-sectional study of all HCWs at the No. 34 Military Hospital located in Freetown, Sierra Leone, was conducted from March 20 to April 10, 2017. Whole blood was collected and screened for HBV markers using a one-step rapid immunochromatographic test with positive samples tested for HBV DNA. Additionally, questionnaires assessing self-reported knowledge of HBV infections were administered to all participants. Data were processed and analyzed using SPSS (version 17.0) software.

RESULTS:

A total of 211 HCWs were included in this study with a median age of 39.0 years (range: 18-59). Of the participating HCWs, 172 (81.5%) participants were susceptible (all markers negative), 21(10.0%) were current HBV (HBsAg positive) and nine (4.3%) were considered immune because of past infection (HBsAg negative and anti-HBc positive; anti-HBs positive). Additionally, nine (4.3%) participants displayed immunity to the virus as a result of prior hepatitis B vaccination (only anti-HBs positive). Of the 21 HCWs with positive HBsAg, 13 (61.9%) had detectable HBV DNA. There was a significantly lower risk for current HBV infection among HCWs older than 39 years (OR 0.337, p = 0.046). In addition, only 14 (6.6%), 73 (34.6%) and 82 (38.9%) participants in this survey had adequate knowledge about the clinical outcome, routes of transmission, and correct preventive measures of HBV infection, respectively.

CONCLUSIONS:

HCWs in Sierra Leone lacked adequate knowledge of the hepatitis B virus. Additionally, the low coverage rate of hepatitis B vaccination among HCWs fails to meet WHO recommendations, leaving many of the sampled HCWs susceptible to infection. This study reaffirms the need for more intensive training for HCWs in addition to strengthening vaccination programmes to protect HCWs against HBV in Sierra Leone.

• Authors: Yu-Ling Qin, Bo Li, Yue-Su Zhou, Xin Zhang, Lei Li, Bing Song, Peng Liu, Yue Yuan, Zhong-Peng Zhao, Jun Jiao, Jing Li, Yi Sun, Stephen Sevalie, Joseph E Kanu, Ya-Jun Song, Jia-Fu Jiang, Foday Sahr, Tian-Jun Jiang, Chinese Military Medical Experts Group in Sierra Leone
• Journal: BMC infectious diseases (BMC Infect Dis) Vol. 18 Issue 1 Pg. 315 (07 09 2018) ISSN: 1471-2334 [Electronic] England
• PMID: 29986658 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Surface Antigens
• Hepatitis B Vaccines

Topics

• Adolescent
• Adult
• Cross-Sectional Studies
• Female
• Health Knowledge, Attitudes, Practice
• Health Personnel (statistics & numerical data)
• Hepatitis B (epidemiology, prevention & control)
• Hepatitis B Surface Antigens (blood)
• Hepatitis B Vaccines
• Hepatitis B virus (pathogenicity)
• Humans
• Male
• Middle Aged
• Prevalence
• Sierra Leone (epidemiology)
• Surveys and Questionnaires
• Vaccination (statistics & numerical data)