Abstract | BACKGROUND: Due to difficulties in predicting recurrences in colorectal cancer stages II and III, reliable prognostic biomarkers could be a breakthrough for individualized treatment and follow-up. OBJECTIVE: METHODS: A panel of 92 oncology-related proteins was analyzed with proximity extension assays, in plasma from a cohort of 261 colorectal cancer patients with stage II-IV. The survival analyses were corrected for disease stage and age, and the recurrence analyses were corrected for disease stage. The significance threshold was adjusted for multiple comparisons. RESULTS: The plasma proteins expression levels had a greater prognostic relevance in disease stage III colorectal cancer than in disease stage II, and for overall survival than for time to recurrence. Osteoprotegerin was the only biomarker candidate in the protein panel that had a statistical significant association with overall survival (P = .00029). None of the proteins were statistically significantly associated with time to recurrence. CONCLUSIONS:
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Authors | Helgi Birgisson, Kostas Tsimogiannis, Eva Freyhult, Masood Kamali-Moghaddam |
Journal | Translational oncology
(Transl Oncol)
Vol. 11
Issue 4
Pg. 1034-1043
(Aug 2018)
ISSN: 1936-5233 [Print] United States |
PMID | 29982101
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. |