Effects of liraglutide, metformin and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: A randomized trial.

Abstract

AIMS/INTRODUCTION:

To compare the effects of gliclazide, liraglutide and metformin on body composition in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease.

MATERIALS AND METHODS:

A total of 85 patients were randomly allocated to receive gliclazide (n = 27), liraglutide (n = 29) or metformin (n = 29) monotherapy for 24 weeks. Body composition was measured using dual-energy X-ray absorptiometry.

RESULTS:

Liraglutide and metformin reduced total, trunk, limb, android and gynoid fat mass; this also led to weight reduction. However, gliclazide treatment produced no significant changes in weight or fat mass, likely because reductions in fat mass were concomitant with increases in lean tissue mass. Blood glucose concentrations and glycated hemoglobin levels improved in all treatment arms; levels of the latter were lower in patients treated with liraglutide and metformin. Serum alanine aminotransferase concentrations decreased in all treatment arms, whereas serum aspartate aminotransferase concentrations were reduced only by liraglutide and metformin. In all patients, weight loss and total, trunk, limb, and android fat mass reductions were positively correlated with decreases in serum alanine aminotransferase and aspartate aminotransferase levels, whereas reductions in waist circumference were positively correlated with lower serum alanine aminotransferase levels.

CONCLUSIONS:

Compared with gliclazide, liraglutide and metformin monotherapies result in greater weight loss, reductions in body fat mass, and better blood glucose control among type 2 diabetes mellitus patients with non-alcoholic fatty liver disease. Reductions in weight, fat mass and waist circumference favorably affect hepatic function.

• Authors: Wen-Huan Feng, Yan Bi, Ping Li, Ting-Ting Yin, Cai-Xia Gao, Shan-Mei Shen, Li-Jun Gao, Dong-Hui Yang, Da-Long Zhu
• Journal: Journal of diabetes investigation (J Diabetes Investig) Vol. 10 Issue 2 Pg. 399-407 (Mar 2019) ISSN: 2040-1124 [Electronic] Japan
• PMID: 29957886 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

Chemical References

• Biomarkers
• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• hemoglobin A1c protein, human
• Liraglutide
• Metformin
• Gliclazide

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (analysis)
• Blood Glucose (analysis)
• Body Composition (drug effects)
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Female
• Follow-Up Studies
• Gliclazide (therapeutic use)
• Glycated Hemoglobin (analysis)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Liraglutide (therapeutic use)
• Liver Function Tests
• Male
• Metformin (therapeutic use)
• Middle Aged
• Non-alcoholic Fatty Liver Disease (drug therapy, metabolism)
• Prognosis
• Prospective Studies
• Young Adult