Abstract | BACKGROUND: CASE PRESENTATION: A 27-year-old Chinese woman was administered dexamethasone for a skin allergy, but her general condition rapidly deteriorated over a month. She was subsequently hospitalized for typical clinical features of Cushing's syndrome. Endocrinological investigation confirmed severe hypercortisolism along with elevated plasma adrenocorticotropin hormone ( ACTH). However, magnetic resonance imaging (MRI) revealed no pituitary adenoma. Abdominal contrast-enhanced computed tomography (CT) revealed a 6.5 cm heterogeneous right adrenal mass with mildly contrast enhancement. The tumor was found during a routine physical check-up at a local hospital 16 months ago; however, the patient did not have any symptoms and did not seek further medical attention at that time. Laparoscopic resection of the right adrenal tumor led to a rapid remission of Cushing's syndrome. Based on pathological findings and the presence of normal catecholamine metabolites in her serum and urine, the patient was diagnosed with noncatecholamine-secreting pheochromocytoma. Immunohistochemical staining of the adrenal tumor revealed positive staining for CRH and negative staining for ACTH. CONCLUSIONS:
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Authors | Bao-Ping Wang, Lei-Lei Yang, Hao Wang, Qing He, Zhong-Shu Ma, Yi Lin, Chang-Xin Jiang, Hao-Ran Sun, Ming Liu |
Journal | BMC endocrine disorders
(BMC Endocr Disord)
Vol. 18
Issue 1
Pg. 41
(Jun 19 2018)
ISSN: 1472-6823 [Electronic] England |
PMID | 29921267
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Corticotropin-Releasing Hormone
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Topics |
- Adrenal Gland Neoplasms
(complications, metabolism, pathology)
- Adult
- Corticotropin-Releasing Hormone
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Paraneoplastic Endocrine Syndromes
(etiology)
- Pheochromocytoma
(complications, metabolism, pathology)
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