Roles of Aldolase Family Genes in Human Cancers and Diseases.

Abstract

The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic functions through protein-protein interactions or epigenetic modifications have been reported in recent years. Using high-throughput screening and -omics database integration, aldolase has been validated as an independent clinical prognostic marker of human cancers. Therefore, the aim of this review was to provide potential clinical value from in silico predictions and also summarize well-known signaling axes or phenotypes in various cancer types. Finally, we discuss the role of aldolase in the treatment of human diseases and cancers.

• Authors: Yu-Chan Chang, Yi-Chieh Yang, Chia-Ping Tien, Chih-Jen Yang, Michael Hsiao
• Journal: Trends in endocrinology and metabolism: TEM (Trends Endocrinol Metab) Vol. 29 Issue 8 Pg. 549-559 (08 2018) ISSN: 1879-3061 [Electronic] United States
• PMID: 29907340 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Aldehyde-Lyases

Topics

• Aldehyde-Lyases (metabolism)
• Biomarkers, Tumor (metabolism)
• Humans
• Neoplasms (diagnosis, metabolism)