Aldehyde-Lyases

Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.

Also Known As:

Networked: 34 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Da'dara, Akram A: 1 article (01/2021)
2.	Pirovich, David B: 1 article (01/2021)
3.	Skelly, Patrick J: 1 article (01/2021)
4.	Chang, Yu-Chan: 1 article (01/2018)
5.	Chen, Yixing: 1 article (01/2018)
6.	Hsiao, Michael: 1 article (01/2018)
7.	Lian, Jiabian: 1 article (01/2018)
8.	Tien, Chia-Ping: 1 article (01/2018)
9.	Xia, Lu: 1 article (01/2018)
10.	Yang, Chih-Jen: 1 article (01/2018)

Related Diseases

1.	Liver Diseases (Liver Disease) 07/01/1960 - "[Contribution to the study of serum transaminases and aldolases in liver diseases. " 06/15/1962 - "[Clinical experiences in the determination of transaminases, aldolases, dehydrogenases, isomerases, peptidases and other modern serum enzyme reactions with special reference to liver diseases and heart infarct]."
2.	Fructose Intolerance (Intolerance, Fructose) 01/01/1974 - "Studies on liver aldolases in hereditary fructose intolerance." 09/15/2000 - "Our results show that the Arg(303)-->Gln substitution is a novel mutation causing hereditary fructose intolerance and provide a functional demonstration that Arg(303), a conserved residue in all vertebrate aldolases, has a dominant role in substrate binding during enzyme catalysis."
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/1978 - "For clarification of this question, the immunoperoxidase technique was used to locate aldolases A, B, and C in one type of fast-growing hepatoma, the LF hepatoma and, by comparison, in normal adult liver. " 01/01/1978 - "Location of adult and fetal aldolases A, B, and C by immunoperoxidase technique in LF fast-growing rat hepatomas." 07/27/1970 - "Resurgence of two fetal-type of aldolases (A and C) in some fast-growing hepatomas." 02/01/1970 - "The identity of the aldolases isolated from rat muscle and primary hepatoma." 06/01/1981 - "These results indicate that, during azo-dye hepatocarcinogenesis, (a) several cell types synthesize foetal aldolases: oval and transitional cells, hepatoma cells and sinusoidal cells; (b) only hepatoma cells and not hepatocytes located in hyperplastic nodules can express both foetal and adult aldolases. "
4.	Neoplasms (Cancer) 01/01/2018 - "Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. " 02/10/1973 - "[Fetal aldolases and liver tumors]." 01/01/2021 - "In this review, we note the several inhibitors that have been synthesized with high specificity for the aldolases of pathogens and cancer cells and have been shown to inhibit classical enzyme activity and moonlighting functions. " 08/01/1991 - "Immunohistochemically, aldolases A and C were found localized in all RCC tissues (n = 10); aldolase B was faintly stained in only a few tumor cells of two cases (20%). " 12/01/1967 - "Fructokinase, triokinase, and aldolases in liver tumors of the rat."
5.	Carcinogenesis 08/01/1991 - "Since it is generally accepted that RCC are derived from renal proximal tubules, these findings indicate that aldolase B, the predominant isozyme in the normal case, changes into aldolases A and C during carcinogenesis and that serum aldolase A could be a new useful biomarker for RCC."

Related Drugs and Biologics

1.	Transaminases (Aminotransferases)
2.	Enzymes
3.	Fructose-Bisphosphate Aldolase (Aldolase)
4.	Phosphoric Monoester Hydrolases (Phosphatases)
5.	Biomarkers (Surrogate Marker)
6.	Messenger RNA (mRNA)
7.	Pyruvate Kinase
8.	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)
9.	Proteins (Proteins, Gene)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Lasers (Laser)