Abstract | Background: Methods: Results: The data obtained from MTT assay showed that WIN 55212-2 could attenuate cell proliferation; however, AM251 was less effective in this regard. Our results showed that WIN 55212-2 considerably reduced cancer cell invasiveness, while AM251 exhibited a converse effect. Moreover, CB1 activation resulted in decreased expression of MMP-2 and MMP-9. Conclusion: Our findings clarifies that CB1 receptors are responsible for anti-invasive effects in the K562 cell line.
|
Authors | Fatemeh Gholizadeh, Mohammad Hossein Ghahremani, Shima Aliebrahimi, Amir Shadboorestan, Seyed Nasser Ostad |
Journal | Iranian biomedical journal
(Iran Biomed J)
Vol. 23
Issue 2
Pg. 153-8
(03 2019)
ISSN: 2008-823X [Electronic] Iran |
PMID | 29883990
(Publication Type: Journal Article)
|
Chemical References |
- Benzoxazines
- Cannabinoids
- Morpholines
- Naphthalenes
- Piperidines
- Pyrazoles
- Receptor, Cannabinoid, CB1
- AM 251
- (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
|
Topics |
- Benzoxazines
(pharmacology)
- Cannabinoids
(pharmacology)
- Dose-Response Relationship, Drug
- Humans
- K562 Cells
- Morpholines
(pharmacology)
- Naphthalenes
(pharmacology)
- Neoplasm Invasiveness
(pathology)
- Piperidines
(pharmacology)
- Pyrazoles
(pharmacology)
- Receptor, Cannabinoid, CB1
(agonists, analysis, metabolism)
|