Regulating the regulator: Bhlhe40 directly keeps IL-10 in check.

Abstract

In this issue of JEM, two complementary manuscripts by Huynh et al. (https://doi.org/10.1084/jem.20171704) and Yu et al. (https://doi.org/10.1084/jem.20170155) demonstrate that the transcription factor Bhlhe40 acts as a repressor of IL-10 production during infection with Mycobacterium tuberculosis or Toxoplasma gondii. Deletion of Bhlhe40 in both cases resulted in chronic infection and increased pathogen load as a consequence of increased IL-10 production.

• Authors: Leona Gabryšová, Anne O'Garra
• Journal: The Journal of experimental medicine (J Exp Med) Vol. 215 Issue 7 Pg. 1767-1769 (07 02 2018) ISSN: 1540-9538 [Electronic] United States
• PMID: 29880485 (Publication Type: Journal Article, Comment)
• Copyright: © 2018 Gabryšová and O'Garra.

Chemical References

• Interleukin-10

Topics

• Humans
• Interleukin-10
• Mycobacterium tuberculosis
• Tuberculosis