Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide
BPC 157, particular anti-
ulcer peptide that heals different organs lesions when given as a
therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (
ulcerative colitis and now
multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the
therapy. However, having managed these two points, stomach cell protection and endothelium protection, either one or together, even much more than standard cytoprotective agents do,
BPC 157 employed large scale of its beneficial effects seen in various organs. Providing endothelium protection,
BPC 157 was shown to prevent formation and reverse established
thrombosis in anastomosed abdominal aorta as well as
venous thrombosis after inferior caval vein occlusion, and attenuate
bleeding prolongation and
thrombocytopenia after
amputation, without or with
anticoagulants, or venous occlusion, and finally counteract effect of
L-NAME and/or
L- arginine. Now, with
BPC 157 application, we reveal the third most important part of the cytoprotection concept: with the stomach cell and endothelium protection to recover mucosal integrity,
BPC 157 as prototype cytoprotective agent should also control blood vessel function, depending upon injury, perforated defect or vessel obstruction. After a perforated injury (i.e., stomach),
BPC 157 therapy activates blood vessels "running" towards defect. After obstruction (i.e., inferior caval vein),
BPC 157 activates vessels "running" towards bypassing defect, collaterals functioning. Reestablished blood flow, and largely reversed injurious course may practically implement the cytoprotection concept.