Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.

Abstract

OBJECTIVE:

To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.

DESIGN:

Prospective cohort study.

SETTING:

Not applicable.

PATIENT(S):

Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks' gestation.

RESULT(S):

After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ≤ 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ≥ 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3).

CONCLUSION(S):

AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.

• Authors: Brianna M Lyttle Schumacher, Anne Marie Z Jukic, Anne Z Steiner
• Journal: Fertility and sterility (Fertil Steril) Vol. 109 Issue 6 Pg. 1065-1071.e1 (06 2018) ISSN: 1556-5653 [Electronic] United States
• PMID: 29871793 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Anti-Mullerian Hormone

Topics

• Abortion, Spontaneous (blood, diagnosis)
• Adult
• Anti-Mullerian Hormone (analysis, blood)
• Biomarkers (blood)
• Cohort Studies
• Female
• Fertilization (physiology)
• Humans
• Pregnancy
• Pregnancy Trimester, First (blood)
• Pregnancy Trimester, Second (blood)
• Prognosis
• Risk Factors