Immunochemical Diagnosis of Multiple Myeloma.

Abstract

The diagnostic potentialities of complex immunochemical analysis of the serum and daily urine were evaluated in 118 patients with multiple myeloma. In 95 patients, we observed secretion of monoclonal intact immunoglobulins with heavy chains G (N=69), A (N=19), and M (N=4) and biclonal secretion of paraproteins G and A (N=3). Bence-Jones protein was detected in the sera and daily urine of 16 patients and Bence-Jones proteinuria alone was detected in 3 patients. The diagnostic sensitivity of serum immunoelectrophoresis in multiple myeloma is 94.1%. Analysis of paraproteinuria is particularly important in Bence-Jones myeloma, when paraprotein excretion may be not associated with paraproteinemia. Complex study by immunoelectrophoretic and immunoturbidimetric methods in multiple myeloma increases the diagnostic sensitivity to 99.2%.

• Authors: N V Lyubimova, Yu S Timofeev, V M Abaev, O M Votyakova, N E Kushlinskii
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 165 Issue 1 Pg. 84-87 (May 2018) ISSN: 1573-8221 [Electronic] United States
• PMID: 29797132 (Publication Type: Journal Article)

Chemical References

• Bence Jones Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Bence Jones Protein (metabolism)
• Female
• Humans
• Immunoelectrophoresis
• Male
• Middle Aged
• Multiple Myeloma (diagnosis, immunology, metabolism)
• Paraproteinemias (metabolism)