Use of Sugammadex in a Patient with Myotonic Dystrophy Undergoing Laparoscopic Cholecystectomy.

Abstract

A 37-year-old female patient with myotonic dystrophy was scheduled for laparoscopic cholecystectomy for gall stone under general anesthesia with continuous propofol infusion. Rocuronium was administered with careful monitoring using TOF- Watch®, measuring train-of-four count (Tc), TOF ratio (Tr), and posttetanic count The total amount of rocuronium was 70 mg ; 0.6 mg .kg⁻1 for anesthetic induction and 0.3 mg .kg⁻1 when Tc exceeded 1. When the operation was completed, Tc was 4, Tr was uncountable and she showed reaction to calling her name. Then sugammadex 2 mg .kg⁻1, rapidly antagonized the neuromuscular block, such that the Tr recovered to 100% but tidal volume was 250 ml in 3 minutes. Additional dorsage of sugammadex, 2 mg .kg⁻1, was required for tidal volume to recover to 530 ml. After 20 minutes of first administration of sugammadex, we extubated the tracheal tube without respiratory depression. To avoid respiratory depression, we did not use postoperative opioids. Intraoperative transversus abdominis plane block and postoperative thoracic epidural block with ropivacaine were successful for postoperative pain relief.

• Authors: Rieko Uno, Shoko Matsuda, Kohei Murao, Kumiko Nakamura, Michiyo Shirakawa, Koh Shingu
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 66 Issue 5 Pg. 550-553 (May 2017) ISSN: 0021-4892 [Print] Japan
• PMID: 29693947 (Publication Type: Case Reports, Journal Article)

Chemical References

• Androstanols
• gamma-Cyclodextrins
• Sugammadex
• Rocuronium
• Propofol

Topics

• Adult
• Androstanols
• Anesthesia, Epidural
• Anesthesia, General
• Cholecystectomy, Laparoscopic
• Female
• Humans
• Myotonic Dystrophy (surgery)
• Nerve Block
• Neuromuscular Blockade
• Propofol
• Respiratory Insufficiency
• Rocuronium
• Sugammadex
• gamma-Cyclodextrins