Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples.

Abstract

Objective:

To detect the aberrant expression of circulating miRNAs and explore the potential early diagnostic biomarkers in patients with Parkinson's disease (PD).

Methods:

Plasma samples were collected from 25 treatment-naïve PD-diagnosed patients and 25 healthy controls followed by a real-time PCR-based miRNA screening analysis of neuron disease-related miRNAs.

Results:

A subset of miRNAs with aberrant expression levels in the plasma of PD-diagnosed patients were identified including upregulation of miR-27a and downregulation of let-7a, let-7f, miR-142-3p, and miR-222 with the AUC values more than 0.8 derived from the receiver operating characteristic curves.

Conclusions:

The high sensitivity and specificity of the circulating miRNAs may enable early diagnosis of PD. The study provides a group of novel miRNA candidates for detecting PD.

• Authors: Lei Chen, Junxiu Yang, Jinhui Lü, Shanshan Cao, Qian Zhao, Zuoren Yu
• Journal: Brain and behavior (Brain Behav) Vol. 8 Issue 4 Pg. e00941 (04 2018) ISSN: 2162-3279 [Electronic] United States
• PMID: 29670823 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• MicroRNAs

Topics

• Biomarkers (blood)
• Down-Regulation
• Female
• Humans
• Male
• MicroRNAs (blood)
• Middle Aged
• Parkinson Disease (blood, diagnosis)
• ROC Curve
• Real-Time Polymerase Chain Reaction
• Sensitivity and Specificity
• Up-Regulation