Growth inhibitory effect of LH-RH analogs on human breast cancer cells.

Abstract

The antiproliferative effect of two LH-RH agonists (Pro 9-LH-RH ethylamide and D Ser(t BU)6 Aza Gly 10-LH-RH, ICI 118630) on the human breast cancer cell line CG5 is reported. Although ineffective when used alone, both analogs inhibited in a dose-dependent fashion the growth stimulatory effect of estradiol. LH-RH analogs did not influence the growth inhibitory effect of tamoxifen and medroxyprogesterone acetate. Likewise, these compounds neither modified basal estrogen and progesterone receptor levels nor prevented estrogen-induced increase of progesterone receptor. A marked antiproliferative effect of the analogs was also seen in cells stimulated with other mitogens, such as insulin and epidermal growth factor.

• Authors: G Scambia, P B Panici, G Baiocchi, L Perrone, C Gaggini, S Iacobelli, S Mancuso
• Journal: Anticancer research (Anticancer Res) 1988 Jan-Feb Vol. 8 Issue 1 Pg. 187-90 ISSN: 0250-7005 [Print] Greece
• PMID: 2965864 (Publication Type: Journal Article)

Chemical References

• Receptors, Estrogen
• Receptors, Progesterone
• Tamoxifen
• Gonadotropin-Releasing Hormone
• Estradiol
• Medroxyprogesterone Acetate
• Medroxyprogesterone

Topics

• Breast Neoplasms (drug therapy, pathology)
• Cell Division (drug effects)
• Estradiol (pharmacology)
• Gonadotropin-Releasing Hormone (analogs & derivatives, pharmacology, therapeutic use)
• Humans
• Medroxyprogesterone (analogs & derivatives, pharmacology)
• Medroxyprogesterone Acetate
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• Tamoxifen (pharmacology)
• Tumor Cells, Cultured