SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF IMIDAZO[2,1- b][1,3,4]THIADIAZOLE DERIVATIVES.

Abstract

In this paper, a series of imidazo[2,l-b][1,3,4]thiadiazoles have been prepared by reacting 2-amino-1,3,4-thiadiazole with various phenacyl bromides in alcohol. The structures of all the derivatives were con- firmed by IR, NMR and mass spectroscopy. All the derivatives have been tested for cytostatic activity against human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), murine leukemia cell line (L1210), and antiviral activity. Among the tested compounds, derivatives 5b, 5c, and 7a were cytostatic between 49-63 mM against Hela and 7g was cytotoxic at 23 mM against L1210 and CEM cell lines. Compounds 5h and 7h emerged as antiviral agents with slight activity against influenza A and B.

• Authors: Arpit Katiyar, Basavaraj Metikurki, Sarala Prafulla, Sujeet Kumar, Satyaprakash Kushwaha, Dominique Schols, Erik De Clercq, Subhas S Karki
• Journal: Acta poloniae pharmaceutica (Acta Pol Pharm) Vol. 73 Issue 4 Pg. 937-947 (07 2016) ISSN: 0001-6837 [Print] Poland
• PMID: 29648719 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Antiviral Agents
• Thiadiazoles

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Antiviral Agents (chemical synthesis, pharmacology)
• HeLa Cells
• Humans
• Leukemia L1210
• Thiadiazoles (chemical synthesis, chemistry, pharmacology)