Venous thromboembolism (VTE) is a common
vascular disease and a major cause of mortality. This study intended to explore the
biomarkers associated with VTE by bioinformatics analyses.Based on Gene Expression Omnibus (GEO) database, the GSE19151 expression profile data were downloaded. The differentially expressed genes (DEGs) between single VTE (sVTE)/recurrent VTE (rVTE) and control were identified. Then, pathway enrichment analysis of DEGs were performed, followed by
protein-
protein interaction (PPI) network construction.Total 433 upregulated and 222 downregulated DEGs were obtained between sVTE and control samples. For rVTE versus control, 625 upregulated and 302 downregulated DEGs were identified. The overlap DEGs were mainly enriched in the pathways related to ribosome,
cancer, and
immune disease. The DEGs specific to rVTE were enriched in several pathways, such as
nod-like receptor signaling pathway. In the PPI network, 2 clusters of VTE genes, including
ribosomal protein family genes and
NADH family-
ubiquinol-
cytochrome genes, were identified, such as
ribosomal protein L9 (RPL9), RPL5, RPS20, RPL23, and
tumor protein p53 (TP53).The
nod-like receptor signaling pathway,
ribosomal protein family genes, such as RPL9, RPL5, RPS20, and RPL23, and DEG of TP53 may have the potential to be used as targets for diagnosis and treatment of VTE.