Abstract | AIM: METHODS: In this study, serum IL-34 levels were assessed by enzyme-linked immunosorbent assay in 19 healthy controls and 175 patients with chronic HBV infection undergoing biopsy. The frequently used serological markers of liver fibrosis were based on laboratory indexes measured at the Clinical Laboratory of the Second Affiliated Hospital of Anhui Medical University. Liver stiffness was detected by transient elastography with FibroTouch. The relationships of non-invasive makers of liver fibrosis and IL-34 levels with inflammation and fibrosis were analyzed. The diagnostic value of IL-34 and other liver fibrosis makers were evaluated using areas under the receiver operating characteristic curves, sensitivity and specificity. RESULTS: Serum IL-34 levels were associated with inflammatory activity in the liver, and IL-34 levels differed among phases of chronic HBV infection (P = 0.001). By comparing serum IL-34 levels among patients with various stages of liver fibrosis determined by liver biopsy, we found that IL-34 levels ≥ 15.83 pg/mL had a high sensitivity of 86.6% and a specificity of 78.7% for identifying severe fibrosis (S3-S4). Furthermore, we showed that IL-34 is superior to the fibrosis-4 score, one of the serum makers of liver fibrosis, in identifying severe liver fibrosis and early cirrhosis in patients with HBV-related liver fibrosis in China. CONCLUSION:
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Authors | Yin-Qiu Wang, Wen-Jun Cao, Yu-Feng Gao, Jun Ye, Gui-Zhou Zou |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 24
Issue 12
Pg. 1312-1320
(Mar 28 2018)
ISSN: 2219-2840 [Electronic] United States |
PMID | 29599606
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- IL34 protein, human
- Interleukins
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Topics |
- Adolescent
- Biomarkers
(blood)
- Biopsy
- Case-Control Studies
- China
- Elasticity Imaging Techniques
- Enzyme-Linked Immunosorbent Assay
- Hepatitis B, Chronic
(blood, pathology, virology)
- Humans
- Interleukins
(blood)
- Liver
(pathology, virology)
- Liver Cirrhosis
(blood, pathology, virology)
- ROC Curve
- Retrospective Studies
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