Abstract | RATIONALE: Sjögren syndrome (SS) is frequently associated with ulcerative keratitis, which is difficult to treat due to lacrimal tear deficiency and inflammation of the ocular surface. PATIENT CONCERNS: We report the successful additive effect of a matrix regenerating agent (RGTA, Cacicol) in SS patients with severe superficial ulcerative keratitis resistant to conventional therapy. DIAGNOSES: Retrospective, noncomparative case series of patients with primary or secondary SS associated with chronic diffuse keratitis. INTERVENTIONS: OUTCOMES: RGTA treatment led to a rapid and marked decrease of ocular pain, burning, irritation, foreign body sensation, and improvement of visual acuity. Total diffuse keratitis healing occurred after several months of treatment. Discontinuation of RGTA administration led to the recurrence of severe keratitis; re-introduction of RGTA was successful. No local or systemic adverse effects related to treatment were reported. LESSONS: RGTA treatment was effective and safe in this small series of 3 patients suffering from SS associated with recurrent or chronic superficial ulcerative keratitis resistant to conventional therapy.
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Authors | Franck Fajnkuchen, Denis Barritault, Audrey Giocanti-Aurégan |
Journal | Medicine
(Medicine (Baltimore))
Vol. 97
Issue 10
Pg. e9935
(Mar 2018)
ISSN: 1536-5964 [Electronic] United States |
PMID | 29517701
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glycosaminoglycans
- OTR4120
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Topics |
- Administration, Topical
- Aged, 80 and over
- Corneal Ulcer
(drug therapy, etiology)
- Female
- Glycosaminoglycans
(administration & dosage)
- Humans
- Middle Aged
- Retrospective Studies
- Sjogren's Syndrome
(complications)
- Time Factors
- Treatment Outcome
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