Effects of testosterone supplement treatment in hypogonadal adult males with T2DM: a meta-analysis and systematic review.

Abstract

PURPOSE:

Testosterone supplement treatment (TST) is a classic therapy for hypogonadal men with type 2 diabetes mellitus (T2DM), but the effects of TST in different studies are inconsistent. We conducted this meta-analysis to evaluate the precise role of TST in hypogonadal men with T2DM.

METHODS:

PubMed, Embase, Cochrane Library and Web of Science were searched to identify qualified randomized controlled trials (RCTs). Pooled mean differences (MDs) with 95% confidence intervals (CIs) were calculated to measure the specific effects of TST. Trial sequential analysis was performed to verify the pooled results.

RESULTS:

A total of eight RCTs were enrolled in our meta-analysis, including 596 hypogonadal participants with T2DM. Compared with comparators, TST can significantly improve glycemic control by reducing homeostatic model assessment of insulin resistance (MD - 0.79, 95% CI - 1.23 to - 0.34), fasting glucose (MD - 0.98, 95% CI - 1.13 to - 0.54), fasting insulin (MD - 2.47, 95% CI - 3.99 to - 0.95) and HbA1c% (MD - 0.45, 95% CI - 0.73 to - 0.16). In addition, TST can result in a decline in cholesterol (MD - 0.29, 95% CI - 0.38 to - 0.19) and triglyceride (MD - 0.37, 95% CI - 0.59 to - 0.15).

CONCLUSION:

Our results indicated that TST can improve glycemic control and decrease TC and TG in hypogonadal patients with T2DM. We recommend TST during the anti-diabetic therapy in these patients.

• Authors: Jianzhong Zhang, Bin Yang, Wenhui Xiao, Xiao Li, Hongjun Li
• Journal: World journal of urology (World J Urol) Vol. 36 Issue 8 Pg. 1315-1326 (Aug 2018) ISSN: 1433-8726 [Electronic] Germany
• PMID: 29511802 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Androgens
• Blood Glucose
• Insulin
• Testosterone

Topics

• Adult
• Androgens (therapeutic use)
• Blood Glucose (metabolism)
• Confidence Intervals
• Diabetes Mellitus, Type 2 (complications, metabolism)
• Humans
• Hypogonadism (complications, drug therapy, metabolism)
• Insulin
• Male
• Middle Aged
• Randomized Controlled Trials as Topic
• Testosterone (therapeutic use)