Abstract | INTRODUCTION: MATERIALS AND METHODS: One hundred patients with type 2 diabetic mellitus were divided into 3 groups of non-DN, early DN, and clinical DN, based on 24-hour urinary albumin levels. Hemoglobin A1c, biochemical indicators, β2-microglobulin, and 24-hour urine albumin levels were assessed. Enzyme linked immunosorbent assay was applied to determine the serum concentrations of DHA, advanced glycation end products, fractalkine, superoxide dismutase, and tumor necrosis factor-α. RESULTS: Lower serum DHA and superoxide dismutase and higher serum β2-microglobulin and 24-hour urine albumin levels were associated with clinical DN, compared to no DN and early DN. The reductions in serum DHA levels were different among the patients with early and clinical DN, stratified by sex, body mass index, and serum lipid levels. Serum DHA significantly correlated positively with superoxide dismutase and negatively with fractalkine and tumor necrosis factor-α in the patients with DN. CONCLUSIONS:
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Authors | Li Zhou, Di Yao, Songqing Zhao, Yuzhang Jiang, Weiping Lu |
Journal | Iranian journal of kidney diseases
(Iran J Kidney Dis)
Vol. 12
Issue 2
Pg. 91-98
(03 2018)
ISSN: 1735-8604 [Electronic] Iran |
PMID | 29507271
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- CX3CL1 protein, human
- Chemokine CX3CL1
- Inflammation Mediators
- Tumor Necrosis Factor-alpha
- Docosahexaenoic Acids
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Topics |
- Adult
- Aged
- Albuminuria
(blood, diagnosis, etiology)
- Biomarkers
(blood)
- Chemokine CX3CL1
(blood)
- Diabetes Mellitus, Type 2
(blood, complications, diagnosis)
- Diabetic Nephropathies
(blood, diagnosis, etiology)
- Docosahexaenoic Acids
(blood)
- Female
- Humans
- Inflammation Mediators
(blood)
- Kidney
(metabolism)
- Male
- Middle Aged
- Oxidative Stress
- Tumor Necrosis Factor-alpha
(blood)
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