Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity.

Abstract

One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.

• Authors: Matthew Wagener, J Claire Hoving, Hlumani Ndlovu, Mohlopheni J Marakalala
• Journal: Frontiers in immunology (Front Immunol) Vol. 9 Pg. 225 ( 2018) ISSN: 1664-3224 [Print] Switzerland
• PMID: 29487599 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Bacterial Proteins
• CARD Signaling Adaptor Proteins
• CARD9 protein, human
• CLEC7A protein, human
• Lectins, C-Type
• Receptors, Pattern Recognition
• SYK protein, human
• Syk Kinase

Topics

• Bacterial Proteins (immunology)
• CARD Signaling Adaptor Proteins (metabolism)
• Host Microbial Interactions (immunology)
• Humans
• Immunity, Innate
• Lectins, C-Type (metabolism)
• Mycobacterium tuberculosis (immunology)
• Receptors, Pattern Recognition (immunology)
• Signal Transduction (immunology)
• Syk Kinase (metabolism)
• Tuberculosis (immunology, microbiology)