Atherosclerosis, a chronic inflammatory disease in arterial blood vessels, is one of the major causes of death in worldwide. Meanwhile,
periodontal disease is a chronic inflammatory disease caused by
infection with periodontal pathogens such as P. gingivalis (Porphyromonas gingivalis). Several studies have reported association between periodontal
infection and
atherosclerosis, but direct investigation about the effects of periodontal treatment on
atherosclerosis has not been reported. We have planned Japanese local clinics to determine the relationship between
periodontal disease and
atherosclerosis under collaborative with medical and
dental care. A prospective, multicentre, observational study was conducted including 38 medical patients with lifestyle-related diseases in the stable period under consultation at participating medical clinics and 92 periodontal patients not undergoing medical treatment but who were consulting at participating dental clinics. Systemic and periodontal examinations were performed before and after periodontal treatment. At baseline,
LDL-C (
low-density lipoprotein cholesterol) levels and percentage (%) of mobile teeth were positively related to plasma
IgG (
immunoglobulin) antibody titer against P. gingivalis with multivariate analysis. Corresponding to improvements in periodontal clinical parameters
after treatment, right and left max IMT (maximum intima-media thickness) levels were decreased significantly
after treatment (SPT-S: start of supportive periodontal
therapy, SPT-1y: at 1 year under SPT, and SPT-3y: at 3 years under SPT). The present study has clarified our previous univariate analysis results, wherein P. gingivalis
infection was positively associated with progression of
atherosclerosis. Thus, routine screening using plasma
IgG antibody titer against P. gingivalis and periodontal treatment under collaborative with medical and
dental care may prevent cardiovascular accidents caused by
atherosclerosis.