Abstract |
Rett syndrome (RTT) and autism spectrum disorders (ASDs) are not merely expression of brain dysfunction but also reflect the perturbation of physiological/metabolic homeostasis. Accordingly, both disorders appear to be associated with increased vulnerability to toxicants produced by redox imbalance, inflammation, and pollution, and impairment of systemic-detoxifying agents could play a role in the exacerbation of these detrimental processes. To check this hypothesis, the activities of two mechanistically related blood-based enzymes, paraoxonase-1 ( arylesterase, paraoxonase, and lactonase), and lipoprotein-associated phospholipase A2 (Lp-PLA2) were measured in the serum of 79 ASD and 95 RTT patients, and 77 controls. Lactonase and Lp-PLA2 showed a similar trend characterized by significantly lower levels of both activities in ASD compared to controls and RTT (p < 0.001 for all pairwise comparisons). Noteworthy, receiving operator curve (ROC) analysis revealed that lactonase and, mostly, Lp-PLA2 were able to discriminate between ASD and controls (lactonase: area under curve, AUC = 0.660; Lp-PLA2, AUC = 0.780), and, considering only females, between ASD and RTT (lactonase, AUC = 0.714; Lp-PLA2, AUC = 0.881). These results suggest that lactonase and, especially, Lp-PLA2 activities might represent novel candidate biomarkers for ASD.
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Authors | Joussef Hayek, Carlo Cervellati, Ilaria Crivellari, Alessandra Pecorelli, Giuseppe Valacchi |
Journal | Oxidative medicine and cellular longevity
(Oxid Med Cell Longev)
Vol. 2017
Pg. 5694058
( 2017)
ISSN: 1942-0994 [Electronic] United States |
PMID | 29317982
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Aryldialkylphosphatase
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Topics |
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
(blood)
- Adolescent
- Area Under Curve
- Aryldialkylphosphatase
(blood)
- Autism Spectrum Disorder
(diagnosis)
- Biomarkers
(blood)
- Case-Control Studies
- Child
- Child, Preschool
- Diagnosis, Differential
- Female
- Humans
- Male
- Pilot Projects
- ROC Curve
- Rett Syndrome
(diagnosis)
- Young Adult
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