The Contribution of Matrix Metalloproteinase-1 Promoter Genotypes in Taiwan Lung Cancer Risk.

Abstract

BACKGROUND/AIM:

Up-regulation of metallo-proteinase (MMP) proteins has been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. The contribution of MMP1 genotype to lung cancer has been investigated in various countries, though, to our knowledge, not in Taiwan. Therefore, in this study, we focused on the contribution of a polymorphism in the promoter region of MMP1 to lung cancer risk in Taiwan population.

PATIENTS AND METHODS:

Genomic DNA was isolated from peripheral blood of 358 patients with lung cancer and 716 healthy individuals (non-cancer patients). MMP1 rs1799750 polymorphic genotypes of each sample were determined using the typical methodology of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

RESULTS:

The percentages of 2G/2G, 1G/2G, and 1G/1G for MMP1 -1607 genotypes were 34.4%, 41.3% and 24.3% in the disease group and 33.9%, 44.0%, and 22.1% in the control group (p trend=0.6298), respectively. The results of carrier comparisons in dominant and recessive models also support the findings that 1G or 2G appears not to be a determinant allelic biomarker for Taiwan lung cancer.

CONCLUSION:

The MMP1 -1607 1G allele is a non-significant protective biomarker for lung cancer in Taiwan.

• Authors: Te-Chun Shen, Wen-Shin Chang, Chia-Wen Tsai, Che-Yi Chao, Yi-Ting Lin, Chieh-Lun Hsiao, Che-Lun Hsu, Wei-Chun Chen, Te-Chun Hsia, DA-Tian Bau
• Journal: Anticancer research (Anticancer Res) Vol. 38 Issue 1 Pg. 253-257 (01 2018) ISSN: 1791-7530 [Electronic] Greece
• PMID: 29277780 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• MMP1 protein, human
• Matrix Metalloproteinase 1

Topics

• Aged
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lung Neoplasms (genetics)
• Male
• Matrix Metalloproteinase 1 (genetics)
• Middle Aged
• Promoter Regions, Genetic
• Risk Factors
• Taiwan (epidemiology)