Abstract | PURPOSE: The prognostic relevance of primary location of urothelial carcinoma on survival has been poorly investigated. MATERIALS AND METHODS: RESULTS: Of the 1,039 patients 878 (85.3%) and 161 (14.7%) had bladder cancer and upper tract urothelial carcinoma, respectively. Patients with bladder cancer had better performance status and were more likely to be male (p = 0.008 and <0.074, respectively). By a median followup of 4.8 years (IQR 4.0-6.7) 733 patients had died and 925 had experienced disease progression. Overall and progression-free survival did not differ significantly between bladder and upper tract urothelial carcinoma cases (p = 0.3 and 0.7, respectively), even after adjusting for the effects of Bajorin risk group by each tumor location. When upper tract urothelial carcinoma was considered separately, patients with primary ureteral tumors had better overall survival than patients with primary bladder cancer (OR = 0.74, p = 0.047). However, this association did not remain significant after adjusting for Bajorin risk group (p = 0.05). CONCLUSIONS:
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Authors | Marco Moschini, Shahrokh F Shariat, Morgan Rouprêt, Maria De Santis, Joaquim Bellmunt, Cora N Sternberg, Bertrand Tombal, Laurence Collette |
Journal | The Journal of urology
(J Urol)
Vol. 199
Issue 5
Pg. 1149-1157
(05 2018)
ISSN: 1527-3792 [Electronic] United States |
PMID | 29158104
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Transitional Cell
(drug therapy, mortality, pathology)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Platinum Compounds
(therapeutic use)
- Prognosis
- Progression-Free Survival
- Urologic Neoplasms
(drug therapy, mortality, pathology)
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