Adrenomedullin as a Biomarker of Heart Failure.

Abstract

Adrenomedullin (AM) is a vasodilatory peptide originally discovered in human pheochromocytoma tissue. Although AM is highly expressed in the adrenal glands, heart, lungs, and kidneys, vascular endothelium and smooth muscle are thought to be the main source of plasma AM. The AM precursor is processed to AM-glycine, which is then converted to AM-mature through C-terminal amidation. In this process, mid-regional pro-adrenomedullin (MR-proAM) is also produced. Plasma AM, AM-mature, AM-glycine, and MR-proAM levels are all higher in patients with heart failure than healthy subjects in proportional to the disease severity. All molecular forms of AM are prognostic markers for heart failure.

• Authors: Toshio Nishikimi, Yasuaki Nakagawa
• Journal: Heart failure clinics (Heart Fail Clin) Vol. 14 Issue 1 Pg. 49-55 (Jan 2018) ISSN: 1551-7136 [Print] United States
• PMID: 29153200 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Adrenomedullin

Topics

• Adrenomedullin (blood)
• Biomarkers (blood)
• Heart Failure (blood)
• Humans