Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis.

Abstract

Healing of leishmaniasis-a parasitic skin disease-is associated with high levels of secreted interferon (IFN)γ and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A-/- mice are protected against Leishmania (L.) major infections, indicating that IL-17A-predominantly produced by Th17 cells-plays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in susceptible BALB/c mice.

• Authors: Kirsten Dietze-Schwonberg, Beate Lorenz, Susanna Lopez Kostka, Beatrix Schumak, André Gessner, Esther von Stebut
• Journal: Experimental dermatology (Exp Dermatol) Vol. 27 Issue 1 Pg. 101-103 (01 2018) ISSN: 1600-0625 [Electronic] Denmark
• PMID: 29078003 (Publication Type: Letter, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Cytokines
• Il23a protein, mouse
• Interleukin-23 Subunit p19
• Interferon-gamma

Topics

• Animals
• Cytokines (metabolism)
• Dendritic Cells (metabolism)
• Disease Progression
• Interferon-gamma (metabolism)
• Interleukin-23 Subunit p19 (genetics)
• Leishmania major
• Leishmaniasis, Cutaneous (immunology)
• Mice
• Mice, Inbred BALB C
• Polymerase Chain Reaction
• Th17 Cells (cytology, immunology)