Abstract | OBJECTIVE: METHODS: Out of a total of 36 head and neck cancer patients from New Zealand (NZ) (n = 24) and China (n = 12) recruited between June 2015 and December 2016, 33 patients complied with protocol. Of these, 11 NZ patients followed a management protocol; 11 NZ patients and 11 Chinese patients followed a prophylactic protocol. An area of the neck receiving a homogenous radiation dose of > 35 Gy was divided into two equal halves; one half was randomized to Film and the other to either Sorbolene cream (NZ) or Biafine cream (China). Skin reaction severity was measured by Radiation Induced Skin Reaction Assessment Scale and expanded Radiation Therapy Oncology Group toxicity criteria. Skin dose was measured by thermoluminescent dosimeters or gafchromic film. RESULTS: Film decreased overall skin reaction severity (combined Radiation Induced Skin Reaction Assessment Scale score) by 29% and moist desquamation rates by 37% in the Chinese cohort and by 27 and 28%, respectively in the NZ cohort. Mepitel Film did not affect head movements but did not adhere well to the skin, particularly in males with heavy beard stubble, and caused itchiness, particularly in Chinese patients. CONCLUSION:
Mepitel Film reduced acute radiation-induced skin reactions in our head and neck cancer patients, particularly in patients without heavy stubble. Advances in knowledge: This is the first study to confirm the feasibility of using Mepitel Film in head and neck cancer patients.
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Authors | Hayley Wooding, Jing Yan, Ling Yuan, Te-Yu Chyou, Shanbao Gao, Iain Ward, Patries M Herst |
Journal | The British journal of radiology
(Br J Radiol)
Vol. 91
Issue 1081
Pg. 20170298
(Jan 2018)
ISSN: 1748-880X [Electronic] England |
PMID | 29072852
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Radiation-Protective Agents
- Silicones
- mepitel
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Topics |
- Carcinoma, Squamous Cell
(radiotherapy)
- Feasibility Studies
- Female
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Male
- Occlusive Dressings
- Radiation-Protective Agents
- Radiodermatitis
(prevention & control)
- Silicones
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