Interaction between chlorhexidine and fluoride in a mouthrinse solution-a 4-day and 6-week randomized clinical pilot study.

Abstract

OBJECTIVE:

The aim of the present investigation was to study if there is a reduced clinical effect and fluoride retention of a mouthrinse solution containing both chlorhexidine (CHX) and sodium fluoride (NaF).

MATERIAL AND METHODS:

Two clinical trials were designed as double-blind, randomized, cross-over studies. In study I, 16 healthy subjects were asked to rinse twice daily for 1 min during 4 days of no tooth brushing with four solutions: (1) 0.12% CHX + 0.2% NaF, (2) 0.2% NaF, (3) 0.12% CHX, and (4) placebo. In study II, another 16 healthy subjects rinsed with the same four solutions twice daily after tooth brushing during a 6-week period. Plaque formation, gingivitis, and microbiological samples from plaque and saliva, as well as fluoride retention, were analyzed.

RESULTS:

Both studies showed that both CHX + NaF and CHX mouthrinses had the same clinical effect with regards to plaque formation and microflora in plaque and saliva. Similarly, fluoride retention was not altered by the CHX + NaF mouthrinse compared to the NaF solution.

CONCLUSION:

The combination of CHX and NaF in a mouthrinse showed the same clinical effect as the CHX solution. The retention of fluoride in the oral cavity was not affected by the combination of NaF and CHX.

CLINICAL RELEVANCE:

A mouthrinse solution containing a mixture of CHX and NaF may be an interesting product for risk patients for caries and periodontal disease. However, this should be verified in further long-term clinical studies.

• Authors: Oscar Villa, Per Ramberg, Hidekazu Fukui, Claes-Göran Emilson, Georgios Papanikolaou, Lars Heijl, Dowen Birkhed
• Journal: Clinical oral investigations (Clin Oral Investig) Vol. 22 Issue 3 Pg. 1439-1448 (Apr 2018) ISSN: 1436-3771 [Electronic] Germany
• PMID: 29032402 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Mouthwashes
• Sodium Fluoride
• Chlorhexidine

Topics

• Adolescent
• Adult
• Anti-Infective Agents, Local (pharmacology)
• Chlorhexidine (pharmacology)
• Cross-Over Studies
• Dental Plaque (microbiology, prevention & control)
• Double-Blind Method
• Drug Interactions
• Female
• Healthy Volunteers
• Humans
• Male
• Mouthwashes (pharmacology)
• Pilot Projects
• Saliva (microbiology)
• Sodium Fluoride (pharmacology)