A jack of all trades: the RNA-binding protein vigilin.

Abstract

The vigilin family of proteins is evolutionarily conserved from yeast to humans and characterized by the proteins' 14 or 15 hnRNP K homology (KH) domains, typically associated with RNA-binding. Vigilin is the largest RNA-binding protein (RBP) in the KH domain-containing family and one of the largest RBP known to date. Since its identification 30 years ago, vigilin has been shown to bind over 700 mRNAs and has been associated with cancer progression and cardiovascular disease. We provide a brief historic overview of vigilin research and outline the proteins' different functions, focusing on maintenance of genome ploidy, heterochromatin formation, RNA export, as well as regulation of translation, mRNA transport, and mRNA stability. The multitude of associated functions is reflected by the large number of identified interaction partners, ranging from tRNAs, mRNAs, ribosomes and ribosome-associated proteins, to histone methyltransferases and DNA-dependent protein kinases. Most of these partners bind to vigilin's carboxyterminus, and the two most C-terminal KH domains of the protein, KH13 and KH14, represent the main mRNA-binding interface. Since the nuclear functions of vigilins in particular are not conserved, we outline a model for the basal functions of vigilins, as well as those which were acquired during the transition from unicellular organisms to metazoa. WIREs RNA 2017, 8:e1448. doi: 10.1002/wrna.1448 For further resources related to this article, please visit the WIREs website.

• Authors: Matthew Hk Cheng, Ralf-Peter Jansen
• Journal: Wiley interdisciplinary reviews. RNA (Wiley Interdiscip Rev RNA) Vol. 8 Issue 6 (11 2017) ISSN: 1757-7012 [Electronic] United States
• PMID: 28975734 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 Wiley Periodicals, Inc.

Chemical References

• Neoplasm Proteins
• RNA, Messenger
• RNA, Neoplasm
• RNA-Binding Proteins
• high density lipoprotein binding protein
• RNA, Transfer

Topics

• Animals
• Cardiovascular Diseases (genetics, metabolism, pathology)
• Evolution, Molecular
• Humans
• Neoplasm Proteins (genetics, metabolism)
• Neoplasms (genetics, metabolism, pathology)
• Protein Domains
• RNA, Messenger (genetics, metabolism)
• RNA, Neoplasm (genetics, metabolism)
• RNA, Transfer (genetics, metabolism)
• RNA-Binding Proteins (genetics, metabolism)