Abstract | Context: Objective: The aim of this study was to assess the GLP-1 secretory and glucometabolic effects of endogenously released bile, with and without concomitant single-dose administration of metformin in patients with type 2 diabetes. Design: Randomized, placebo-controlled, and double-blinded crossover study. Setting: This study was conducted at Center for Diabetes Research, Gentofte Hospital, Denmark. Patients: Interventions: Main Outcome Measure: Plasma GLP-1 excursions as measured by baseline-subtracted area under the curve. Results: Single-dose metformin further enhanced bile acid-mediated induction of GLP-1 secretion (P = 0.02), whereas metformin alone did not increase plasma GLP-1 concentrations compared with placebo (P = 0.17). Metformin, both with (P = 0.02) and without (P = 0.02) concomitant cholecystokinin-induced gallbladder emptying, elicited reduced plasma glucose excursions compared with placebo. No GLP-1-mediated induction of insulin secretion or suppression of glucagon was observed. Conclusions:
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Authors | Andreas Brønden, Anders Albér, Ulrich Rohde, Jens F Rehfeld, Jens J Holst, Tina Vilsbøll, Filip K Knop |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 102
Issue 11
Pg. 4153-4162
(11 01 2017)
ISSN: 1945-7197 [Electronic] United States |
PMID | 28938439
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2017 Endocrine Society |
Chemical References |
- Bile Acids and Salts
- Blood Glucose
- Placebos
- Glucagon-Like Peptide 1
- Cholecystokinin
- Metformin
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Topics |
- Aged
- Bile Acids and Salts
(pharmacology)
- Blood Glucose
(metabolism)
- Cholecystokinin
(pharmacology)
- Cross-Over Studies
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Gallbladder Emptying
(drug effects, physiology)
- Glucagon-Like Peptide 1
(metabolism)
- Humans
- Male
- Metformin
(administration & dosage)
- Middle Aged
- Placebos
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