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Near-infrared triggered co-delivery of doxorubicin and quercetin by using gold nanocages with tetradecanol to maximize anti-tumor effects on MCF-7/ADR cells.

Abstract
Previously, combination chemotherapy of doxorubicin (DOX) and quercetin (QUR) was developed to improve antitumor effects and reverse multidrug resistance and several biocompatible nanocarriers, such as liposomes and micelles, were validated for their targeted delivery. In this study, we report a near-infrared (NIR)-responsive drug delivery system based on DOX and QUR co-loaded gold nanocages (AuNCs) with biotin modification. The system was simply fabricated by filling the hollow interiors of AuNCs with tetradecanol (TD), a phase-change material with a melting point of 39°C, to control the drug release. The main cause of multidrug resistance (MDR) of DOX is the overexpression of P-glycoprotein (P-gp), which can be inhibited by QUR. Thus the combination chemotherapy of DOX and QUR may provide a promising strategy for MDR. The in vitro cytotoxicity of DOX and QUR at several fixed mass ratios was carried out and showed that the combination index (CI) was the smallest at the ratio of 1:0.2, indicating that the best synergistic effect was achieved. The resultant nanocomplex (abbreviated as BPQD-AuNCs) exhibited fast release (80% released in 20min) and strong cytotoxicity against MCF-7/ADR cells (IC50, 1.5μg/mL) under NIR irradiation. Additionally, BPQD-AuNCs were found to generate a large amount of reactive oxygen species (ROS), to inhibit P-gp expression and ATP activity. Taken together, the results show that BPQD-AuNC is a prospective nano-delivery system for overcoming multidrug-resistant cancer.
AuthorsZhipeng Zhang, Shaohui Xu, Yun Wang, Yanna Yu, Fangzhou Li, Hao Zhu, Yuanyuan Shen, Shengtang Huang, Shengrong Guo
JournalJournal of colloid and interface science (J Colloid Interface Sci) Vol. 509 Pg. 47-57 (Jan 01 2018) ISSN: 1095-7103 [Electronic] United States
PMID28881205 (Publication Type: Journal Article)
CopyrightCopyright © 2017. Published by Elsevier Inc.
Chemical References
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Drug Carriers
  • Fatty Alcohols
  • Reactive Oxygen Species
  • Biotin
  • Gold
  • Doxorubicin
  • Quercetin
  • myristyl alcohol
Topics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 (metabolism)
  • Antineoplastic Agents (administration & dosage, chemistry)
  • Apoptosis
  • Biotin (chemistry)
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Survival
  • Doxorubicin (administration & dosage, chemistry)
  • Drug Carriers (chemistry)
  • Drug Liberation
  • Drug Resistance, Neoplasm
  • Fatty Alcohols (chemistry)
  • Gold (chemistry)
  • Humans
  • Light
  • Metal Nanoparticles (chemistry)
  • Particle Size
  • Phototherapy
  • Quercetin (administration & dosage, chemistry)
  • Reactive Oxygen Species (metabolism)

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