Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?

Abstract

PURPOSE:

Plasma concentrations of several amino acids (AAs) are positively correlated with obesity. The aim of this study was to examine if selected plasma AAs are associated with weight regain from 2 to 4 years after Roux-en-Y gastric bypass (RYGB).

METHODS:

In a prospective study with 165 patients, we examined the relationship between plasma aromatic AAs (AAAs), branched chain AAs (BCAAs), and total cysteine (tCys) 2 years after RYGB, with BMI at 2 years and with weight change from 2 to 4 years after surgery. Analyses were adjusted for relevant covariates.

RESULT:

The investigated AAs at 2 years correlated positively with BMI at 2 years (P ≤ 0.003 for all). BCAAs and AAAs at 2 years correlated inversely with % weight loss from 0 to 2 years (P = 0.002 and P = 0.001, respectively), while the association was not significant for tCys (r = -0.14, P = 0.08). Plasma tCys at 2 years correlated positively with BMI at 4 years (P = 0.010) and with weight regain from 2 to 4 years (P = 0.015).

CONCLUSION:

Plasma AAAs, BCAAs, and tCys at 2 years were associated with BMI at 2 years. In addition, plasma AAAs and BCAAs at 2 years were associated with weight loss from 0 to 2 years, while tCys at 2 years was associated with weight regain from 2 to 4 years after RYGB. These results suggest that high tCys at 2 years may be used as a prognostic marker for future weight regain. The study was registered in ClinicalTrials.gov (NCT0 1270451).

• Authors: Susanna E Hanvold, Kathrine J Vinknes, Nasser E Bastani, Cheryl Turner, Elin B Løken, Tom Mala, Helga Refsum, Anne-Marie Aas
• Journal: European journal of nutrition (Eur J Nutr) Vol. 57 Issue 7 Pg. 2629-2637 (Oct 2018) ISSN: 1436-6215 [Electronic] Germany
• PMID: 28856439 (Publication Type: Journal Article)

Chemical References

• Amino Acids

Topics

• Adiposity (physiology)
• Amino Acids (metabolism)
• Gastric Bypass
• Humans
• Obesity (metabolism, surgery)
• Prospective Studies
• Weight Gain (physiology)
• Weight Loss (physiology)