Abstract | BACKGROUND: METHODS: Blood samples were obtained immediately before cardiac catheterization in 179 consecutive patients with suspected CAD. Detailed lipid profiling was performed using a VAP cholesterol test. CAD severity was categorized angiographically as no/minor CAD (<20% luminal diameter stenosis [LDS]), moderate CAD (20% to 74% LDS) and severe CAD (>75% LDS of any major coronary vessel). RESULTS: Patients with severe CAD had significantly higher LDL4 and triglycerides, and lower total HDL, HDL2, HDL3, LDL2 and LDL3 compared to patients with no/minor CAD (p < .05 for all). Multivariate analysis showed high LDL4 as an independent predictive of severe CAD. ROC analysis showed an area under the curve of 0.62 (p < .0001) with a cut-point of >16.9 mg/dL to predict severe CAD with a sensitivity of 53% and specificity of 79%. CONCLUSION: Elevated LDL4 levels are associated with severe CAD. Further large-scale investigations are required to evaluate the utility of LDL4 in predicting CAD severity.
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Authors | Rahul Chaudhary, Denny Mathew, Kevin Bliden, Udaya S Tantry, Tushar Sharma, Martin G Gesheff, Christopher J Franzese, Shachi Pandya, Peter P Toth, Paul A Gurbel |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 33
Issue 11
Pg. 1979-1984
(11 2017)
ISSN: 1473-4877 [Electronic] England |
PMID | 28787217
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, HDL
- Lipoproteins, LDL
- Triglycerides
- Cholesterol
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Topics |
- Aged
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Coronary Artery Disease
(physiopathology)
- Female
- Humans
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Multivariate Analysis
- Risk Factors
- Sensitivity and Specificity
- Triglycerides
(blood)
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